Folate and iron difunctionalized multiwall carbon nanotubes as dual-targeted drug nanocarrier to cancer cells

	Folate and iron difunctionalized multiwall carbon nanotubes as dual-targeted drug nanocarrier to cancer cells
	Li, Ruibin 1; Wu, Ren'an 1; Zhao, Liang 1; Hu, Zhengyan 1; Guo, Shujing 2; Pan, Xiulian 2; Zou, Hanfa 1
刊名	carbon
	2011-04-01
卷号	49 期号:5 页码:1797-1805
ISSN号	0008-6223
通讯作者	吴仁安
产权排序	1,1
中文摘要	folate and iron difunctionalized multiwall carbon nanotubes as dual-targeted drug nanocarrier to cancer cells
英文摘要	a nanomaterial, folate and iron difunctionalized multiwall carbon nanotube (fa-mwcnt@fe), has been synthesized by conjugating folate and iron nanoparticles with oxidized multi-walled carbon nanotubes, and applied as a dual-targeted drug nanocarrier to deliver doxorubicin into hela cells with the assistance of an external magnetic field. the prepared fa-mwcnt@fe was characterized by x-ray diffraction, transmission electron microscopy and infrared spectroscopy. this nanocarrier has a sufficient load capacity (doxorubicin/fa-mwcnt@fe, 32 mu g/mg) and a prolonged release property controlled by near infrared radiation. it also demonstrated both biologically (active) and magnetically (passive) targeting capabilities toward hela cells in vitro with ca. 6-fold higher delivery efficiency of doxorubicin than free doxorubicin. (c) 2011 elsevier ltd. all rights reserved.
学科主题	物理化学
WOS标题词	science & technology ; physical sciences ; technology
类目[WOS]	chemistry, physical ; materials science, multidisciplinary
研究领域[WOS]	chemistry ; materials science
关键词[WOS]	core-shell nanoparticles ; intracellular delivery ; controlled-release ; functionalization ; transporters ; design ; bioapplications ; doxorubicin ; discovery ; therapy
收录类别	SCI
语种	英语
WOS记录号	WOS:000287952700034
公开日期	2012-07-09
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/115190]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Li, Ruibin,Wu, Ren'an,Zhao, Liang,et al. Folate and iron difunctionalized multiwall carbon nanotubes as dual-targeted drug nanocarrier to cancer cells[J]. carbon,2011,49(5):1797-1805.
APA	Li, Ruibin.,Wu, Ren'an.,Zhao, Liang.,Hu, Zhengyan.,Guo, Shujing.,...&Zou, Hanfa.(2011).Folate and iron difunctionalized multiwall carbon nanotubes as dual-targeted drug nanocarrier to cancer cells.carbon,49(5),1797-1805.
MLA	Li, Ruibin,et al."Folate and iron difunctionalized multiwall carbon nanotubes as dual-targeted drug nanocarrier to cancer cells".carbon 49.5(2011):1797-1805.