Radiosynthesis, biodistribution and micro-SPECT imaging study of dendrimer-avidin conjugate

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2011-2017年

	Radiosynthesis, biodistribution and micro-SPECT imaging study of dendrimer-avidin conjugate
	Xu, Xiaoping（许晓平） ; Zhang, Yuanqing（张元庆） ; Wang, Xudong（王旭东） ; Guo, Xunxiang ; Zhang, Xuezhu（张雪竹） ; Qi, Yujin（漆玉金） ; Shen, Yu-Mei（沈玉梅）
刊名	BIOORGANIC & MEDICINAL CHEMISTRY
	2011
卷号	19 期号:5 页码:1643
ISSN号	0968-0896
英文摘要	Partially acetylated generation five polyamidoamine (PAMAM) dendrimer (G5-Ac) was reacted with biotin and 2-(p-isothiocyanatobenzyl)-6-methyl-diethylenetria minepentaacetic acid (1B4M-DTPA), respectively to form the complex Bt-G5-Ac-1B4M which was further conjugated with avidin to give the conjugate Av-G5-Ac-1B4M. Then both of the conjugates were radiolabeled with technetium-99m ((99m)Tc), respectively. Their in vitro cellular uptake study shows that the conjugate of Av-G5-Ac-1B4M-(99m)Tc exhibits much higher cellular uptake in HeLa cells than that of Bt-G5-Ac-1B4M-(99m)Tc. Accordingly the following evaluation such as in vitro/in vivo stability, biodistribution and micro-SPECT imaging was observed only for the conjugate of Av-G5-Ac-1B4M-(99m)Tc. (C) 2011 Elsevier Ltd. All rights reserved.
收录类别	SCI
语种	英语
WOS记录号	WOS:000287740200007
公开日期	2012-07-04
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/9573]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
推荐引用方式 GB/T 7714	Xu, Xiaoping,Zhang, Yuanqing,Wang, Xudong,et al. Radiosynthesis, biodistribution and micro-SPECT imaging study of dendrimer-avidin conjugate[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2011,19(5):1643.
APA	Xu, Xiaoping.,Zhang, Yuanqing.,Wang, Xudong.,Guo, Xunxiang.,Zhang, Xuezhu.,...&Shen, Yu-Mei.(2011).Radiosynthesis, biodistribution and micro-SPECT imaging study of dendrimer-avidin conjugate.BIOORGANIC & MEDICINAL CHEMISTRY,19(5),1643.
MLA	Xu, Xiaoping,et al."Radiosynthesis, biodistribution and micro-SPECT imaging study of dendrimer-avidin conjugate".BIOORGANIC & MEDICINAL CHEMISTRY 19.5(2011):1643.