Pseudoferic acids A-C, three novel triterpenoids from the root bark of Pseudolarix kaempferi

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	Pseudoferic acids A-C, three novel triterpenoids from the root bark of Pseudolarix kaempferi
	Wu, Xing-De 2,3; He, Juan 2; Shen, Yu 4; Dong, Liao-Bin 2,3; Pan, Zheng-Hong 2; Xu, Gang2 ; Gong, Xun2 ; Song, Liu-Dong 1; Leng, Ying 4; Li, Yan2
刊名	TETRAHEDRON LETTERS
	2012-02-15
卷号	53 期号:7 页码:800-803
关键词	Pseudolarix kaempferi Triterpenoids 11 beta-HSD1 inhibitory activity
ISSN号	0040-4039
通讯作者	Song, LD (reprint author), Kunming Med Univ, Coll Pharmacol, Kunming 650031, Peoples R China, ynsld@126.com ; qinshizhao@mail.kib.ac.cn
英文摘要	Three novel triterpenoids, pseudoferic acids A and B (1 and 2) possessed a unique 16,24-cyclo-26-norlanostane skeleton, and pseudoferic acid C (3) featured a cis-fused D/E-ring system, were isolated from the root bark of Pseudolarix kaempferi. Their structures were elucidated on the basis of extensive spectroscopic analysis. Compounds 2 and 3 exhibited weak inhibitory activities against 110-HSD1 (110-hydroxysteroid dehydrogenase 1) with IC50 values of 0.44 (mouse 11 beta-HSD1) and 0.75 mu M (human 11 beta-HSD1), respectively. (C) 2011 Elsevier Ltd. All rights reserved.
学科主题	Chemistry, Organic
类目[WOS]	Chemistry, Organic
研究领域[WOS]	Chemistry
关键词[WOS]	TU-JIN-PI ; CYCLOARTENOL SYNTHASE ; CONSTITUENTS ; STEREOCHEMISTRY ; DITERPENOIDS ; ANGIOGENESIS ; LANOSTEROL
收录类别	SCI ; IC
资助信息	National Basic Research Program of China (973 Program)[2009CB522303, 2011CB915503]; National Natural Science Foundation of China[90813004, U0932602]; Chinese Academy of sciences[2009311211011, 2009312311024]; State Key Laboratory of Phytochemistry and Plant Resources in West China[P2010-ZZ05]
语种	英语
WOS记录号	WOS:000300518900019
公开日期	2012-06-07
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn:8080/handle/151853/10505]
专题	昆明植物研究所_资源植物与生物技术所级重点实验室
作者单位	1.Kunming Med Univ, Coll Pharmacol, Kunming 650031, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Wu, Xing-De,He, Juan,Shen, Yu,et al. Pseudoferic acids A-C, three novel triterpenoids from the root bark of Pseudolarix kaempferi[J]. TETRAHEDRON LETTERS,2012,53(7):800-803.
APA	Wu, Xing-De.,He, Juan.,Shen, Yu.,Dong, Liao-Bin.,Pan, Zheng-Hong.,...&Zhao, Qin-Shi.(2012).Pseudoferic acids A-C, three novel triterpenoids from the root bark of Pseudolarix kaempferi.TETRAHEDRON LETTERS,53(7),800-803.
MLA	Wu, Xing-De,et al."Pseudoferic acids A-C, three novel triterpenoids from the root bark of Pseudolarix kaempferi".TETRAHEDRON LETTERS 53.7(2012):800-803.