Globostelletins J-S, isomalabaricanes with unusual cyclopentane sidechains from the marine sponge Rhabdastrella globostellata

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Globostelletins J-S, isomalabaricanes with unusual cyclopentane sidechains from the marine sponge Rhabdastrella globostellata
	Li, Jin 1; Zhu, Huajie 2; Ren, Jinwei 1; Deng, Zhiwei 3; de Voogd, Nicole J.4; Proksch, Peter 5; Lin, Wenhan 1
刊名	TETRAHEDRON
	2012-01-14
卷号	68 期号:2 页码:559-565
关键词	Marine sponge Rhabdastrella globostellata Globostelletins J-R Structural elucidation Protein kinase inhibition
ISSN号	0040-4020
通讯作者	Lin, WH (reprint author), Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China, whlin@bjmu.edu.cn
英文摘要	Nine new isomalabaricane-type triterpenoids namely globostelletins J-R (1-9) were isolated from the marine sponge Rhabdastrella globostellata. Their structures were established on the basis of extensive spectroscopic data analysis including IR, MS, 1D and 2D NMR, and CD spectra. Globostelletins J-R are characterized by the presence of an unusual cyclopentane unit linked at different positions of sidechains. These unprecedented structures enriched a number of new skeletons in isomalabaricane family. The biogenetic relationship of the isolated compounds is postulated. All compounds were tested for the inhibitory activities against human tumor-related protein kinases. (C) 2011 Elsevier Ltd. All rights reserved.
学科主题	Chemistry ; Organic
类目[WOS]	Chemistry, Organic
研究领域[WOS]	Chemistry
关键词[WOS]	JASPIS-STELLIFERA ; STELLETTA-GLOBOSTELLATA ; A-D ; TRITERPENES ; DERIVATIVES ; NORTRITERPENOIDS ; SESTERTERPENES ; CONSTITUENTS ; TENUIS
收录类别	SCI ; IC
资助信息	NSFC[30672607]; National Hi-Tech 863-Projects[2010DFA31610]; BMBF/MOST
语种	英语
WOS记录号	WOS:000299443900018
公开日期	2012-06-07
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn:8080/handle/151853/10395]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China 2.CAS, Kunming Inst Bot, Kunming 650204, Peoples R China 3.Beijing Normal Univ, Analyt & Testing Ctr, Beijing 100075, Peoples R China 4.Natl Museum Nat Hist, NL-2300 RA Leiden, Netherlands 5.Univ Dusseldorf, Inst Pharmaceut Biol & Biotechnol, D-40225 Dusseldorf, Germany
推荐引用方式 GB/T 7714	Li, Jin,Zhu, Huajie,Ren, Jinwei,et al. Globostelletins J-S, isomalabaricanes with unusual cyclopentane sidechains from the marine sponge Rhabdastrella globostellata[J]. TETRAHEDRON,2012,68(2):559-565.
APA	Li, Jin.,Zhu, Huajie.,Ren, Jinwei.,Deng, Zhiwei.,de Voogd, Nicole J..,...&Lin, Wenhan.(2012).Globostelletins J-S, isomalabaricanes with unusual cyclopentane sidechains from the marine sponge Rhabdastrella globostellata.TETRAHEDRON,68(2),559-565.
MLA	Li, Jin,et al."Globostelletins J-S, isomalabaricanes with unusual cyclopentane sidechains from the marine sponge Rhabdastrella globostellata".TETRAHEDRON 68.2(2012):559-565.