Adaptive foraging of a prominent human intestinal symbiont in gnotobiotic mice | |
Xu J | |
刊名 | Science |
2005 | |
期号 | 9 |
关键词 | Adaptive foraging of a prominent human intestinal symbiont in gnotobiotic mice |
中文摘要 | Germ-free mice were maintained on polysaccharide-rich or simple-sugar diets and colonized for 10 days with an organism also found in human guts, Bacteroides thetaiotaomicron, followed by whole-genome transcriptional profiling of bacteria and mass spectrometry of cecal glycans. We found that these bacteria assembled on food particles and mucus, selectively induced outer-membrane polysaccharide-binding proteins and glycoside hydrolases, prioritized the consumption of liberated hexose sugars, and revealed a capacity to turn to host mucus glycans when polysaccharides were absent from the diet. This flexible foraging behavior should contribute to ecosystem stability and functional diversity. |
英文摘要 | Germ-free mice were maintained on polysaccharide-rich or simple-sugar diets and colonized for 10 days with an organism also found in human guts, Bacteroides thetaiotaomicron, followed by whole-genome transcriptional profiling of bacteria and mass spectrometry of cecal glycans. We found that these bacteria assembled on food particles and mucus, selectively induced outer-membrane polysaccharide-binding proteins and glycoside hydrolases, prioritized the consumption of liberated hexose sugars, and revealed a capacity to turn to host mucus glycans when polysaccharides were absent from the diet. This flexible foraging behavior should contribute to ecosystem stability and functional diversity. |
学科主题 | 功能基因组 |
公开日期 | 2012-06-01 |
内容类型 | 期刊论文 |
源URL | [http://ir.qibebt.ac.cn:8080/handle/337004/961] |
专题 | 青岛生物能源与过程研究所_单细胞中心 |
推荐引用方式 GB/T 7714 | Xu J. Adaptive foraging of a prominent human intestinal symbiont in gnotobiotic mice[J]. Science,2005(9). |
APA | Xu J.(2005).Adaptive foraging of a prominent human intestinal symbiont in gnotobiotic mice.Science(9). |
MLA | Xu J."Adaptive foraging of a prominent human intestinal symbiont in gnotobiotic mice".Science .9(2005). |
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