Biotransformation of Aconitum Alkaloids Before and After the Combination of Radix Aconiti Preparata by Rat Intestinal Flora Using Semiquantitative Analysis Method of Electrospray Ionization Mass Spectrometry

	Biotransformation of Aconitum Alkaloids Before and After the Combination of Radix Aconiti Preparata by Rat Intestinal Flora Using Semiquantitative Analysis Method of Electrospray Ionization Mass Spectrometry
	Wang XY ; Pi ZF ; Liu WL ; Song FR ; Liu ZQ ; Liu SY
刊名	chemical journal of chinese universities-chinese
	2011
卷号	32 期号:7 页码:1526-1531
关键词	TOF-MS BACTERIA CARMIECHAELI METABOLITE
ISSN号	0251-0790
通讯作者	liu sy
中文摘要	the biotransformation of diester-diterpenoid alkaloid, monoester-diterpenoid alkaloid and lipo-alkaloid in the decoctions of chinese medicine pairs by rat intestinal flora was studied using electrospray ionization tandem mass spectrometry. the semiquantitative method of mass spectrometry was established for the analysis of aconitum alkaloids before and after biotransformation. the content changes of aconitum alkaloids caused by rat intestinal flora was analyzed in the biotransformation process of the decoctions of radix aconiti preparata with bulbus fritillariae thunbergii, rhizoma pinelliae preparatum and ampelopsis japonica. the results showed that after the combination bulbus fritillariae thunbergii increased the content of diester-diterpenoid alkaloids, and rhizoma pinelliae preparatum reduced the content of diester-diterpenoid alkaloids, and ampelopsis japonica almost has no effect for the content of diester-diterpenoid alkaloids in decoction; the rat intestinal flora can more reduce the toxicity of diester-diterpenoid alkaloids and increase the content of lipo-alkaloids. the mechanism of combination and biotransformation of traditional chinese medicine was proposed by the analysis of the content changes of aconitum alkaloids in chinese medicine pairs.
收录类别	SCI收录期刊论文
语种	中文
WOS记录号	WOS:000293303800015
公开日期	2012-06-08
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/44483]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Wang XY,Pi ZF,Liu WL,et al. Biotransformation of Aconitum Alkaloids Before and After the Combination of Radix Aconiti Preparata by Rat Intestinal Flora Using Semiquantitative Analysis Method of Electrospray Ionization Mass Spectrometry[J]. chemical journal of chinese universities-chinese,2011,32(7):1526-1531.
APA	Wang XY,Pi ZF,Liu WL,Song FR,Liu ZQ,&Liu SY.(2011).Biotransformation of Aconitum Alkaloids Before and After the Combination of Radix Aconiti Preparata by Rat Intestinal Flora Using Semiquantitative Analysis Method of Electrospray Ionization Mass Spectrometry.chemical journal of chinese universities-chinese,32(7),1526-1531.
MLA	Wang XY,et al."Biotransformation of Aconitum Alkaloids Before and After the Combination of Radix Aconiti Preparata by Rat Intestinal Flora Using Semiquantitative Analysis Method of Electrospray Ionization Mass Spectrometry".chemical journal of chinese universities-chinese 32.7(2011):1526-1531.