Fabrication of luminescent and mesoporous core-shell structured nanocomposites and their application as drug carrier

	Fabrication of luminescent and mesoporous core-shell structured nanocomposites and their application as drug carrier
	Gai SL ; Yang PP ; Hao JG ; Wang WX ; Niu N ; He F ; Wang D ; Lin J
刊名	microporous and mesoporous materials
	2010
卷号	131 期号:1-3 页码:128-135
关键词	SPRAY-PYROLYSIS NANOCRYSTALLINE Y2O3EU DIFFERENT MORPHOLOGIES SILICA NANOPARTICLES PHOSPHOR PARTICLES PORE DIAMETERS QUANTUM DOTS IN-VITRO RELEASE DELIVERY
ISSN号	1387-1811
通讯作者	yang pp
中文摘要	monodisperse y2o3:eu3+ nanospheres were prepared by a facile urea-based homogeneous precipitation method. core-shell structured bifunctional (mesporous, luminescent) nanocomposite was realized by coating mesoporous silica (ms) on the y2o3:eu3+ spheres via a simple sol-gel process. this nanocomposite was investigated as drug delivery/release carrier using ibuprofen (ibu) as model drug. x-ray diffraction (xrd), scanning electron microscopy (sem), transmission electron microscopy (tem). n-2 adsorption/desorption, fourier transform infrared spectroscopy (ft-ir), and photoluminescence (pl) spectra were employed to characterize the as-prepared materials. the results indicated that the bifunctional nanocomposites with a uniform diameter of about 80 nm possess ordered mesoporous structure and strong red luminescence of eu3+. drug release test reveals that the y2o3:eu3+@sio2 system has favorable drug release properties, especially modified by amino before drug loading. additionally, the ibu-loaded y2o3:eu3+@sio2 system still showed the red luminescence under uv irradiation. and the emission intensity of eu3+ increases with an increase of the cumulative released amount of ibu, making the extent of drug release be easily identified, tracked and monitored by the change of luminescence during the release process and disease therapy. (c) 2009 elsevier inc. all rights reserved.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000276627600017
公开日期	2012-06-06
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/43777]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Gai SL,Yang PP,Hao JG,et al. Fabrication of luminescent and mesoporous core-shell structured nanocomposites and their application as drug carrier[J]. microporous and mesoporous materials,2010,131(1-3):128-135.
APA	Gai SL.,Yang PP.,Hao JG.,Wang WX.,Niu N.,...&Lin J.(2010).Fabrication of luminescent and mesoporous core-shell structured nanocomposites and their application as drug carrier.microporous and mesoporous materials,131(1-3),128-135.
MLA	Gai SL,et al."Fabrication of luminescent and mesoporous core-shell structured nanocomposites and their application as drug carrier".microporous and mesoporous materials 131.1-3(2010):128-135.