Synthesis and characterization of multifunctional poly(glycidyl methacrylate) microspheres and their use in cell separation

	Synthesis and characterization of multifunctional poly(glycidyl methacrylate) microspheres and their use in cell separation
	Dong XQ ; Zheng YH ; Huang YB ; Chen XS ; Jing XB
刊名	analytical biochemistry
	2010
卷号	405 期号:2 页码:207-212
关键词	IRON-OXIDE NANOPARTICLES MAGNETIC NANOPARTICLES TARGETED DELIVERY DRUG-DELIVERY NANOCOMPOSITES NANOCRYSTALS ADHESION BLOOD FLOW
ISSN号	0003-2697
通讯作者	jing xb
中文摘要	multifunctional poly(glycidyl methacrylate) (pgma) microspheres containing magnetic, fluorescent, and cancer cell-specific moieties were prepared in four steps: (i) preparation of parent pgma microspheres by dispersion polymerization and their reaction with ethylenediamine to obtain amino groups, (ii) precipitation of iron ions (fe2+ and fe3+) to form fe3o4 nanoparticles within the microspheres, (iii) consecutive reactions of folic acid with the amino groups on pgma, and (iv) incorporation of fluorescein isothiocyanate into the microspheres. the microspheres were superparamagnetic, highly monodispersive, intensively fluorescent, and capable of recognizing and binding cancer cells that overexpress folic acid receptors. it was demonstrated that with these microspheres, hela cells could be captured from their suspension and easily moved in the direction of the externally applied magnetic field. (c) 2010 elsevier inc. all rights reserved.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000281296300009
公开日期	2012-04-26
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/43507]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Dong XQ,Zheng YH,Huang YB,et al. Synthesis and characterization of multifunctional poly(glycidyl methacrylate) microspheres and their use in cell separation[J]. analytical biochemistry,2010,405(2):207-212.
APA	Dong XQ,Zheng YH,Huang YB,Chen XS,&Jing XB.(2010).Synthesis and characterization of multifunctional poly(glycidyl methacrylate) microspheres and their use in cell separation.analytical biochemistry,405(2),207-212.
MLA	Dong XQ,et al."Synthesis and characterization of multifunctional poly(glycidyl methacrylate) microspheres and their use in cell separation".analytical biochemistry 405.2(2010):207-212.