Biodistribution and toxicity of nanodiamonds in mice after intratracheal instillation

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2004-2010年

	Biodistribution and toxicity of nanodiamonds in mice after intratracheal instillation
	Zhang, XY ; Yin, JL ; Kang, C ; Li, J ; Zhu, Y ; Li, WX ; Huang, Q ; Zhu, ZY
刊名	TOXICOLOGY LETTERS
	2010
卷号	198 期号:2 页码:7
关键词	Nanodiamonds Biodistribution Micro-SPECT Intratracheal instillation Toxicity
ISSN号	0378-4274
通讯作者	Li, WX (reprint author), Chinese Acad Sci, Phys Biol Lab, Shanghai Inst Appl Phys, 2019 Jialuo Rd, Shanghai 201800, Peoples R China
英文摘要	Nanodiamonds (NDs) are receiving increasing attention in materials science and nanotechnology-based industries for a large variety of applications, including protein immobilization, biosensors, therapeutic molecule delivery, and bioimaging. However, limited information is known about their biokinetic behavior and toxicity in vivo. In this article, we investigated the biodistribution of NDs using radiotracer techniques and evaluated its acute toxicity in Kun Ming mice after intratracheal instillation. The biodistribution showed that, besides having the highest retention in the lung, NDs were distributed mainly in the spleen, liver, bone and heart. An analysis of histological morphology and biochemical parameters indicated that NDs could induce dose-dependent toxicity to the lung, liver, kidney and blood. This work provided fundamental data for understanding the biodistribution of NDs and will provide guidance for further study of their toxicity. Crown Copyright (C) 2010 Published by Elsevier Ireland Ltd. All rights reserved.
学科主题	Toxicology
收录类别	SCI
语种	英语
WOS记录号	WOS:000281942800020
公开日期	2012-04-11
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/6854]
专题	上海应用物理研究所_中科院上海应用物理研究所2004-2010年
推荐引用方式 GB/T 7714	Zhang, XY,Yin, JL,Kang, C,et al. Biodistribution and toxicity of nanodiamonds in mice after intratracheal instillation[J]. TOXICOLOGY LETTERS,2010,198(2):7.
APA	Zhang, XY.,Yin, JL.,Kang, C.,Li, J.,Zhu, Y.,...&Zhu, ZY.(2010).Biodistribution and toxicity of nanodiamonds in mice after intratracheal instillation.TOXICOLOGY LETTERS,198(2),7.
MLA	Zhang, XY,et al."Biodistribution and toxicity of nanodiamonds in mice after intratracheal instillation".TOXICOLOGY LETTERS 198.2(2010):7.