| Evidence for Positive Selection on the Leptin Gene in Cetacea and Pinnipedia | |
| Yu, Li1,2; Jin, Wei1,2; Zhang, Xin1,2; Wang, Ding3; Zheng, Jin-song3; Yang, Guang4,5; Xu, Shi-xia4,5; Cho, Soochin6; Zhang, Ya-ping1,2,7 | |
| 刊名 | PLOS ONE
 |
| 2011-10-27 | |
| 卷号 | 6期号:10页码:e26579 |
| 关键词 | ELEPHANT SEAL PUPS HUMAN GROWTH-HORMONE AMINO-ACID SITES BODY-WEIGHT OBESE GENE FUNCTIONAL GENOMICS EPISODIC EVOLUTION PLACENTAL MAMMALS BINDING DOMAIN MARINE MAMMALS |
| ISSN号 | 1932-6203 |
| 通讯作者 | Yu, L (reprint author), Yunnan Univ, Minist Educ, Lab Conservat & Utilizat Bioresource, Kunming 650091, Peoples R China ; yuli1220@yahoo.com.cn ; zhangyp@mail.kiz.ac.cn |
| 中文摘要 | The leptin gene has received intensive attention and scientific investigation for its importance in energy homeostasis and reproductive regulation in mammals. Furthermore, study of the leptin gene is of crucial importance for public health, particularly for its role in obesity, as well as for other numerous physiological roles that it plays in mammals. In the present work, we report the identification of novel leptin genes in 4 species of Cetacea, and a comparison with 55 publicly available leptin sequences from mammalian genome assemblies and previous studies. Our study provides evidence for positive selection in the suborder Odontoceti (toothed whales) of the Cetacea and the family Phocidae (earless seals) of the Pinnipedia. We also detected positive selection in several leptin gene residues in these two lineages. To test whether leptin and its receptor evolved in a coordinated manner, we analyzed 24 leptin receptor gene (LPR) sequences from available mammalian genome assemblies and other published data. Unlike the case of leptin, our analyses did not find evidence of positive selection for LPR across the Cetacea and Pinnipedia lineages. In line with this, positively selected sites identified in the leptin genes of these two lineages were located outside of leptin receptor binding sites, which at least partially explains why co-evolution of leptin and its receptor was not observed in the present study. Our study provides interesting insights into current understanding of the evolution of mammalian leptin genes in response to selective pressures from life in an aquatic environment, and leads to a hypothesis that new tissue specificity or novel physiologic functions of leptin genes may have arisen in both odontocetes and phocids. Additional data from other species encompassing varying life histories and functional tests of the adaptive role of the amino acid changes identified in this study will help determine the factors that promote the adaptive evolution of the leptin genes in marine mammals. |
| 英文摘要 | The leptin gene has received intensive attention and scientific investigation for its importance in energy homeostasis and reproductive regulation in mammals. Furthermore, study of the leptin gene is of crucial importance for public health, particularly for its role in obesity, as well as for other numerous physiological roles that it plays in mammals. In the present work, we report the identification of novel leptin genes in 4 species of Cetacea, and a comparison with 55 publicly available leptin sequences from mammalian genome assemblies and previous studies. Our study provides evidence for positive selection in the suborder Odontoceti (toothed whales) of the Cetacea and the family Phocidae (earless seals) of the Pinnipedia. We also detected positive selection in several leptin gene residues in these two lineages. To test whether leptin and its receptor evolved in a coordinated manner, we analyzed 24 leptin receptor gene (LPR) sequences from available mammalian genome assemblies and other published data. Unlike the case of leptin, our analyses did not find evidence of positive selection for LPR across the Cetacea and Pinnipedia lineages. In line with this, positively selected sites identified in the leptin genes of these two lineages were located outside of leptin receptor binding sites, which at least partially explains why co-evolution of leptin and its receptor was not observed in the present study. Our study provides interesting insights into current understanding of the evolution of mammalian leptin genes in response to selective pressures from life in an aquatic environment, and leads to a hypothesis that new tissue specificity or novel physiologic functions of leptin genes may have arisen in both odontocetes and phocids. Additional data from other species encompassing varying life histories and functional tests of the adaptive role of the amino acid changes identified in this study will help determine the factors that promote the adaptive evolution of the leptin genes in marine mammals. |
| 学科主题 | Life Sciences & Biomedicine - Other Topics |
| WOS标题词 | Science & Technology |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | ELEPHANT SEAL PUPS ; HUMAN GROWTH-HORMONE ; AMINO-ACID SITES ; BODY-WEIGHT ; OBESE GENE ; FUNCTIONAL GENOMICS ; EPISODIC EVOLUTION ; PLACENTAL MAMMALS ; BINDING DOMAIN ; MARINE MAMMALS |
| 收录类别 | SCI |
| 资助信息 | State Key Basic Research and Development Plan[2007CB411600]; National Natural Science Foundation of China[U0836603] |
| 语种 | 英语 |
| WOS记录号 | WOS:000296521400027 |
| 公开日期 | 2011-12-21 |
| 内容类型 | 期刊论文 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/16389]  |
| 专题 | 水生生物研究所_水生生物多样性与资源保护研究中心_期刊论文 |
| 作者单位 | 1.Yunnan Univ, Minist Educ, Lab Conservat & Utilizat Bioresource, Kunming 650091, Peoples R China 2.Yunnan Univ, Minist Educ, Key Lab Microbial Resources, Kunming 650091, Peoples R China 3.Chinese Acad Sci, Inst Hydrobiol, Wuhan, Peoples R China 4.Nanjing Normal Univ, Coll Life Sci, Jiangsu Key Lab Biodivers & Biotechnol, Nanjing, Peoples R China 5.Nanjing Normal Univ, Coll Life Sci, Inst Genet Resources, Nanjing, Peoples R China 6.Creighton Univ, Dept Biol, Omaha, NE 68178 USA 7.Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Li,Jin, Wei,Zhang, Xin,et al. Evidence for Positive Selection on the Leptin Gene in Cetacea and Pinnipedia[J]. PLOS ONE,2011,6(10):e26579. |
| APA | Yu, Li.,Jin, Wei.,Zhang, Xin.,Wang, Ding.,Zheng, Jin-song.,...&Zhang, Ya-ping.(2011).Evidence for Positive Selection on the Leptin Gene in Cetacea and Pinnipedia.PLOS ONE,6(10),e26579. |
| MLA | Yu, Li,et al."Evidence for Positive Selection on the Leptin Gene in Cetacea and Pinnipedia".PLOS ONE 6.10(2011):e26579. |
| 个性服务 |
| 查看访问统计 |
| 相关权益政策 |
| 暂无数据 |
| 收藏/分享 |
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论