Metabolic profiling of cadmium-induced effects in one pioneer intertidal halophyte Suaeda salsa by NMR-based metabolomics

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 中科院海岸带环境过程与生态修复重点实验室 > 污染过程与控制实验室

	Metabolic profiling of cadmium-induced effects in one pioneer intertidal halophyte Suaeda salsa by NMR-based metabolomics
	Liu, Xiaoli 1,2,3; Yang, Cuiyun1,2 ; Zhang, Linbao 1,2,3; Li, Lianzhen1,2 ; Liu, Sujing 1,2; Yu, Junbao1,2 ; You, Liping 1,2,3; Zhou, Di1,2,3 ; Xia, Chuanhai1,2 ; Zhao, Jianmin1,2
刊名	ECOTOXICOLOGY
	2011-08-01
卷号	20 期号:6 页码:1422-1431
关键词	Cadmium Suaeda salsa NMR Metabolomics
ISSN号	0963-9292
通讯作者	Wu, HF, Chinese Acad Sci, Yantai Inst Coastal Zone Res, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China. hfwu@yic.ac.cn
产权排序	[Liu, XL; Yang, CY; Zhang, LB; Li, LZ; Liu, SJ; Yu, JB; You, LP; Zhou, D; Xia, CH; Zhao, JM; Wu, HF] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China; [Liu, XL; Yang, CY; Zhang, LB; Li, LZ; Liu, SJ; Yu, JB; You, LP; Zhou, D; Xia, CH; Zhao, JM; Wu, HF] Chinese Acad Sci, Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China; [Liu, XL; Zhang, LB; You, LP; Zhou, D] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
中文摘要	Cadmium is a non-essential element to living organisms and has become the severe contaminant in both seawater and sediment in the intertidal zones of the Bohai Sea. The halophyte, Suaeda salsa is the pioneer plant in the intertidal zones of Bohai Sea and has been widely applied in environmental sciences. In this study, the dose- and time-dependent effects induced by environmentally relevant concentrations (2, 10 and 50 mu g l(-1)) of cadmium were characterized in S. salsa using NMR-based metabolomics. The levels of amino acids (valine, leucine, glutamate, tyrosine, etc.), carbohydrates (glucose, sucrose and fructose), intermediates of tricarboxylic acid cycle (succinate, citrate, etc.) and osmolyte (betaine) were altered in the S. salsa samples after cadmium exposures. These metabolic biomarkers indicated the elevated protein degradation and disturbances in the osmotic regulation and energy metabolism caused by cadmium in S. salsa. Overall, our results demonstrated the applicability of NMR-based metabolomics for the detection of metabolic biomarkers that could be used for the interpretation of toxicological effects induced by contaminants in the pioneer plant S. salsa in the intertidal zones. In addition, the metabolic biomarkers could be potentially useful for the bio-monitoring of contaminants in the intertidal zones.
英文摘要	Cadmium is a non-essential element to living organisms and has become the severe contaminant in both seawater and sediment in the intertidal zones of the Bohai Sea. The halophyte, Suaeda salsa is the pioneer plant in the intertidal zones of Bohai Sea and has been widely applied in environmental sciences. In this study, the dose- and time-dependent effects induced by environmentally relevant concentrations (2, 10 and 50 mu g l(-1)) of cadmium were characterized in S. salsa using NMR-based metabolomics. The levels of amino acids (valine, leucine, glutamate, tyrosine, etc.), carbohydrates (glucose, sucrose and fructose), intermediates of tricarboxylic acid cycle (succinate, citrate, etc.) and osmolyte (betaine) were altered in the S. salsa samples after cadmium exposures. These metabolic biomarkers indicated the elevated protein degradation and disturbances in the osmotic regulation and energy metabolism caused by cadmium in S. salsa. Overall, our results demonstrated the applicability of NMR-based metabolomics for the detection of metabolic biomarkers that could be used for the interpretation of toxicological effects induced by contaminants in the pioneer plant S. salsa in the intertidal zones. In addition, the metabolic biomarkers could be potentially useful for the bio-monitoring of contaminants in the intertidal zones.
学科主题	Environmental Sciences & Ecology; Toxicology
研究领域[WOS]	Environmental Sciences & Ecology ; Toxicology
关键词[WOS]	V-H+-ATPASE ; SAMPLE-PREPARATION ; OXIDATIVE STRESS ; OSMOTIC-STRESS ; EXPOSURE ; LEAVES ; RESPONSES ; NACL ; TRANSFORMATION ; ACCUMULATION
收录类别	SCI
资助信息	Project of National Science & Technology Pillar Program in "12th Five Year'' Period[2011BAC02B01]; Chinese Academy of Sciences[KZCX2-YW-223, KZCX2-YW-225]; Technology Development Program Projects of Shandong Province[2008GG2000 5006, 2008GG3NS0700]; SDSFC[ZR2009CZ008]; CAS/SAFEA International; Shandong Provincial Key Laboratory of Ecology and Environment in Yellow River Delta[2009KFJJ03]
语种	英语
WOS记录号	WOS:000292689400024
公开日期	2011-11-11
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/5120]
专题	烟台海岸带研究所_污染过程与控制实验室烟台海岸带研究所_滨海湿地实验室烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China 2.Chinese Acad Sci, Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Liu, Xiaoli,Yang, Cuiyun,Zhang, Linbao,et al. Metabolic profiling of cadmium-induced effects in one pioneer intertidal halophyte Suaeda salsa by NMR-based metabolomics[J]. ECOTOXICOLOGY,2011,20(6):1422-1431.
APA	Liu, Xiaoli.,Yang, Cuiyun.,Zhang, Linbao.,Li, Lianzhen.,Liu, Sujing.,...&Wu, Huifeng.(2011).Metabolic profiling of cadmium-induced effects in one pioneer intertidal halophyte Suaeda salsa by NMR-based metabolomics.ECOTOXICOLOGY,20(6),1422-1431.
MLA	Liu, Xiaoli,et al."Metabolic profiling of cadmium-induced effects in one pioneer intertidal halophyte Suaeda salsa by NMR-based metabolomics".ECOTOXICOLOGY 20.6(2011):1422-1431.