Forkhead Transcription Factor 3a (FOXO3a) Modulates Hypoxia Signaling via Up-regulation of the von Hippel-Lindau Gene (VHL) | |
Liu, Xing1; Cai, Xiaolian1; Hu, Bo1; Mei, Zhichao1; Zhang, Dawei1; Ouyang, Gang1; Wang, Jing1; Zhang, Wei1; Xiao, Wuhan1,2 | |
刊名 | JOURNAL OF BIOLOGICAL CHEMISTRY |
2016-12-02 | |
卷号 | 291期号:49页码:25692-25705 |
关键词 | FOXO hypoxia hypoxia-inducible factor (HIF) stress transcription regulation zebrafish pVHL |
ISSN号 | 0021-9258 |
DOI | 10.1074/jbc.M116.745471 |
英文摘要 | FOXO3a, a member of the forkhead homeobox type O (FOXO) family of transcriptional factors, regulates cell survival in response to DNA damage, caloric restriction, and oxidative stress. The von Hippel-Lindau (VHL) tumor suppressor gene encodes a component of the E3 ubiquitin ligase complex that mediates hypoxia-inducible factor degradation under aerobic conditions, thus acting as one of the key regulators of hypoxia signaling. However, whether FOXO3a impacts cellular hypoxia stress remains unknown. Here we show that FOXO3a directly binds to the VHL promoter and up-regulates VHL expression. Using a zebrafish model, we confirmed the up-regulation of vhl by foxo3b, an ortholog of mammalian FOXO3a. Furthermore, by employing the clustered regularly interspaced short palindromic repeats (CRISPR)-associated RNA-guided endonuclease Cas9 (CRISPR/Cas9) technology, we deleted foxo3b in zebrafish and determined that expression of hypoxia-inducible genes was affected under hypoxia. Moreover, foxo3b-null zebrafish exhibited impaired acute hypoxic tolerance, resulting in death. In conclusion, our findings suggest that, by modulating hypoxia-inducible factor activity via up-regulation of VHL, FOXO3a (foxo3b) plays an important role in survival in response to hypoxic stress. |
资助项目 | National Natural Science Foundation in China (NSFC)[31401072] ; Chinese Academy of Sciences Major Scientific and Technological Project[XDA08010208] ; NSFC[31461163003] ; NSFC[91631102] ; NSFC[31671315] |
WOS关键词 | HIGH-ALTITUDE ADAPTATION ; CELL RENAL-CARCINOMA ; OXIDATIVE STRESS ; HIF-ALPHA ; PROTEASOMAL DEGRADATION ; INDUCIBLE FACTORS ; BETA-CATENIN ; PVHL ; PROTEIN ; PATHWAY |
WOS研究方向 | Biochemistry & Molecular Biology |
语种 | 英语 |
出版者 | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC |
WOS记录号 | WOS:000390095300034 |
资助机构 | National Natural Science Foundation in China (NSFC) ; National Natural Science Foundation in China (NSFC) ; National Natural Science Foundation in China (NSFC) ; National Natural Science Foundation in China (NSFC) ; National Natural Science Foundation in China (NSFC) ; National Natural Science Foundation in China (NSFC) ; National Natural Science Foundation in China (NSFC) ; National Natural Science Foundation in China (NSFC) ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; National Natural Science Foundation in China (NSFC) ; National Natural Science Foundation in China (NSFC) ; National Natural Science Foundation in China (NSFC) ; National Natural Science Foundation in China (NSFC) ; National Natural Science Foundation in China (NSFC) ; National Natural Science Foundation in China (NSFC) ; National Natural Science Foundation in China (NSFC) ; National Natural Science Foundation in China (NSFC) ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; National Natural Science Foundation in China (NSFC) ; National Natural Science Foundation in China (NSFC) ; National Natural Science Foundation in China (NSFC) ; National Natural Science Foundation in China (NSFC) ; National Natural Science Foundation in China (NSFC) ; National Natural Science Foundation in China (NSFC) ; National Natural Science Foundation in China (NSFC) ; National Natural Science Foundation in China (NSFC) ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; National Natural Science Foundation in China (NSFC) ; National Natural Science Foundation in China (NSFC) ; National Natural Science Foundation in China (NSFC) ; National Natural Science Foundation in China (NSFC) ; National Natural Science Foundation in China (NSFC) ; National Natural Science Foundation in China (NSFC) ; National Natural Science Foundation in China (NSFC) ; National Natural Science Foundation in China (NSFC) ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; National Natural Science Foundation in China (NSFC) ; National Natural Science Foundation in China (NSFC) ; National Natural Science Foundation in China (NSFC) ; National Natural Science Foundation in China (NSFC) ; National Natural Science Foundation in China (NSFC) ; National Natural Science Foundation in China (NSFC) ; National Natural Science Foundation in China (NSFC) ; National Natural Science Foundation in China (NSFC) ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; National Natural Science Foundation in China (NSFC) ; National Natural Science Foundation in China (NSFC) ; National Natural Science Foundation in China (NSFC) ; National Natural Science Foundation in China (NSFC) ; National Natural Science Foundation in China (NSFC) ; National Natural Science Foundation in China (NSFC) ; National Natural Science Foundation in China (NSFC) ; National Natural Science Foundation in China (NSFC) ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; National Natural Science Foundation in China (NSFC) ; National Natural Science Foundation in China (NSFC) ; National Natural Science Foundation in China (NSFC) ; National Natural Science Foundation in China (NSFC) ; National Natural Science Foundation in China (NSFC) ; National Natural Science Foundation in China (NSFC) ; National Natural Science Foundation in China (NSFC) ; National Natural Science Foundation in China (NSFC) ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; National Natural Science Foundation in China (NSFC) ; National Natural Science Foundation in China (NSFC) ; National Natural Science Foundation in China (NSFC) ; National Natural Science Foundation in China (NSFC) ; National Natural Science Foundation in China (NSFC) ; National Natural Science Foundation in China (NSFC) ; National Natural Science Foundation in China (NSFC) ; National Natural Science Foundation in China (NSFC) ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; Chinese Academy of Sciences Major Scientific and Technological Project ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC ; NSFC |
内容类型 | 期刊论文 |
源URL | [http://ir.ihb.ac.cn/handle/342005/33461] |
专题 | 水生生物研究所_水环境工程研究中心_期刊论文 |
通讯作者 | Xiao, Wuhan |
作者单位 | 1.Chinese Acad Sci, Key Lab Aquat Biodivers & Conservat, Inst Hydrobiol, Wuhan 430072, Peoples R China 2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China |
推荐引用方式 GB/T 7714 | Liu, Xing,Cai, Xiaolian,Hu, Bo,et al. Forkhead Transcription Factor 3a (FOXO3a) Modulates Hypoxia Signaling via Up-regulation of the von Hippel-Lindau Gene (VHL)[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2016,291(49):25692-25705. |
APA | Liu, Xing.,Cai, Xiaolian.,Hu, Bo.,Mei, Zhichao.,Zhang, Dawei.,...&Xiao, Wuhan.(2016).Forkhead Transcription Factor 3a (FOXO3a) Modulates Hypoxia Signaling via Up-regulation of the von Hippel-Lindau Gene (VHL).JOURNAL OF BIOLOGICAL CHEMISTRY,291(49),25692-25705. |
MLA | Liu, Xing,et al."Forkhead Transcription Factor 3a (FOXO3a) Modulates Hypoxia Signaling via Up-regulation of the von Hippel-Lindau Gene (VHL)".JOURNAL OF BIOLOGICAL CHEMISTRY 291.49(2016):25692-25705. |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论