Radiation-induced Delayed Microsatellite Instability in Human Normal Liver HL-7702 Cells

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	Radiation-induced Delayed Microsatellite Instability in Human Normal Liver HL-7702 Cells
	Ye Fei; Zhao Ting; He Pengbo; Liu Xiongxiong; Li Qiang
刊名	Nuclear Physics Review
	2013
卷号	30 页码:494-502
ISSN号	1007-4627
英文摘要	Human normal liver cell line HL-7702 cells were irradiated with high linear energy transfer (LET) ~(12)C~(6+)ions and low-LET X-rays, respectively. Delayed effect in terms of microsatellite instability (MSI) in progenies of the directly irradiated cells and bystander cells, obtained in the way of medium transfer at the 8th passage postirradiation, were examined. The delayed effect induced by the high-LET ~(12)C~(6+)ions was different from that induced by the low-LET X-rays, and a higher incidence of MSI was observed in the progenies of the cells after exposure to the X-rays than to the ~(12)C~(6+)ions. We also found that the delayed effect in the progenies of the bystander cells was much more severe than those of directly irradiated cells. Furthermore, the events of MSI and loss of heterozygosity (LOH) induced by the ionizing radiations were not randomly distributed throughout the genome and specific loci existed indeed. These results imply that the radiation risk to normal tissues is lower in heavy ion therapy than in conventional X-ray radiotherapy, and the analysis of microsatellite loci with MSI high frequency occurrence can be applied to access long-term survival condition and second cancer risk for the patients after radiotherapy.
CSCD记录号	CSCD:5024884
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/59899]
专题	近代物理研究所_兰州重离子研究装置近代物理研究所_生物物理研究室
推荐引用方式 GB/T 7714	Ye Fei,Zhao Ting,He Pengbo,et al. Radiation-induced Delayed Microsatellite Instability in Human Normal Liver HL-7702 Cells[J]. Nuclear Physics Review,2013,30:494-502.
APA	Ye Fei,Zhao Ting,He Pengbo,Liu Xiongxiong,&Li Qiang.(2013).Radiation-induced Delayed Microsatellite Instability in Human Normal Liver HL-7702 Cells.Nuclear Physics Review,30,494-502.
MLA	Ye Fei,et al."Radiation-induced Delayed Microsatellite Instability in Human Normal Liver HL-7702 Cells".Nuclear Physics Review 30(2013):494-502.