Role of autophagy in high linear energy transfer radiation-induced cytotoxicity to tumor cells

doi:10.1111/cas.12422

	Role of autophagy in high linear energy transfer radiation-induced cytotoxicity to tumor cells
	Li, Q (reprint author), Chinese Acad Sci, Inst Modern Phys, 509 Nanchang Rd, Lanzhou 730000, Gansu, Peoples R China.; Li, Q9 ; Furusawa, Y 9; Liu, XX 9; Ye, F 9; Liu, Y 9; Jin, XD 9; Wu, QF 9; Li, FF 9; Zheng, XG 9
刊名	CANCER SCIENCE
	2014
卷号	105 页码:770-778
关键词	Malignant Glioma-cells Heavy-ion Irradiation Prostate-cancer Cells Dna-damage Response High-let Radiation Targeting Autophagy Sh-sy5y Cells A549 Cells Beclin 1 Apoptosis
ISSN号	1347-9032
DOI	10.1111/cas.12422
英文摘要	Heavy-ion radiotherapy has a potential advantage over conventional radiotherapy due to improved dose distribution and a higher biological effectiveness in cancer therapy. However, there is a little information currently available on the cellular and molecular basis for heavy-ion irradiation-induced cell death. Autophagy, as a novel important target to improve anticancer therapy, has recently attracted considerable attention. In this study, the effect of autophagy induced by high linear energy transfer (LET) carbon ions was examined in various tumor cell lines. To our knowledge, our study is the first to reveal that high-LET carbon ions could induce autophagy in various tumor cells effectively, and the autophagic level in the irradiated cells increased in a dose-and LET-dependent manner. The ability of carbon ions to inhibit the activation of the PI3K/Akt pathway rose with increasing their LET. Moreover, modulation of autophagy in tumor cells could modify their sensitivity to high-LET radiation, and inhibiting autophagy accelerated apoptotic cell death, resulting in an increase in radiosensitivity. Our data imply that targeting autophagy might enhance the effectiveness of heavy-ion radiotherapy.
URL标识	查看原文
资助项目	Gansu Provincial Funds for Distinguished Young Scientists[1111RJDA010]
WOS关键词	MALIGNANT GLIOMA-CELLS ; HEAVY-ION IRRADIATION ; PROSTATE-CANCER CELLS ; DNA-DAMAGE RESPONSE ; HIGH-LET RADIATION ; TARGETING AUTOPHAGY ; SH-SY5Y CELLS ; A549 CELLS ; BECLIN 1 ; APOPTOSIS
WOS研究方向	Oncology
语种	英语
出版者	WILEY-BLACKWELL
WOS记录号	WOS:000340602800004
资助机构	Research Project with Heavy-ions at NIRS-HIMAC [13J372] ; Research Project with Heavy-ions at NIRS-HIMAC [13J372] ; National Basic Research Program of China (973 Program) [2010CB834203] ; National Basic Research Program of China (973 Program) [2010CB834203] ; Key Project of National Natural Science Foundation of China [U1232207] ; Key Project of National Natural Science Foundation of China [U1232207] ; National Natural Science Foundation of China [11305223, 11075191, 11205217] ; National Natural Science Foundation of China [11305223, 11075191, 11205217] ; Gansu Provincial Funds for Distinguished Young Scientists [1111RJDA010] ; Gansu Provincial Funds for Distinguished Young Scientists [1111RJDA010]
内容类型	期刊论文
源URL	[http://ir.impcas.ac.cn/handle/113462/18578]
专题	近代物理研究所_医学物理研究室近代物理研究所_生物物理研究室
通讯作者	Li, Q (reprint author), Chinese Acad Sci, Inst Modern Phys, 509 Nanchang Rd, Lanzhou 730000, Gansu, Peoples R China.
作者单位	1.Tang, Bo 2.Qing, Hong] Beijing Inst Technol, Sch Life Sci, Beijing 100081, Peoples R China 3.Deng, Yulin 4.Ma, Hong 5.Dong, Yiming 6.[Wang, Xiao] China Inst Atom Energy, Beijing 102413, Peoples R China 7.[Li, Qiang] Lanzhou Inst Modern Phys, Lanzhou 730000, Peoples R China 8.[Gao, Qian] Gen Hosp Peoples Liberat Army Hosp 301, Beijing 100853, Peoples R China 9.[Ran, Yuanyuan 10.Wang, Ran
推荐引用方式 GB/T 7714	Li, Q ,Li, Q,Furusawa, Y,et al. Role of autophagy in high linear energy transfer radiation-induced cytotoxicity to tumor cells[J]. CANCER SCIENCE,2014,105:770-778.
APA	Li, Q .,Li, Q.,Furusawa, Y.,Liu, XX.,Ye, F.,...&Dai, ZY.(2014).Role of autophagy in high linear energy transfer radiation-induced cytotoxicity to tumor cells.CANCER SCIENCE,105,770-778.
MLA	Li, Q ,et al."Role of autophagy in high linear energy transfer radiation-induced cytotoxicity to tumor cells".CANCER SCIENCE 105(2014):770-778.