Inactive and mutagenic effects induced by carbon beams of different LET values in a red yeast strain

doi:10.1016/j.nimb.2010.05.100

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	Inactive and mutagenic effects induced by carbon beams of different LET values in a red yeast strain
	Wang, Jufang; Lu, Dong; Wu, Xin; Sun, Haining; Ma, Shuang; Li, Renmin; Li, Wenjian
刊名	NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS
	2010-09-01
卷号	268 期号:17-18 页码:2719-2723
关键词	Inactivation Mutation Carbon beams Linear energy transfer Yeast
ISSN号	0168-583X
DOI	10.1016/j.nimb.2010.05.100
英文摘要	To evaluate biological action of microorganism exposed to charged particles during the long distance space exploration. Induction of inactivation and mutation in a red yeast strain Rhodotorula glutinis AY 91015 by carbon beams of different LET values (14.9-120 0 keV mu m(-1)) was investigated It was found that survival curves were exponential, and mutation curves were linear for all LET values The dependence of inactivation cross section on LET approached saturation near 120 0 keV mu m(-1) The imitation cross section saturated when LET was higher than 582 keV mu m(-1) Meanwhile, the highest RBE(I) for inactivation located at 120 0 key mu m(-1) and the highest RBE(m) for mutation was at 58.2 key mu m(-1) The experiments imply that the most efficient mutagenic part of the depth dose profile of carbon ion is at the plateau region with intermediate LET value in which energy deposited is high enough to Induce mutagenic lesions but too low to induce over kill effect in the yeast cells (C) 2010 Elsevier B V All rights reserved
资助项目	Chinese Academy of Sciences[KJCX2-YW-N34-2] ; Chinese Academy of Sciences[0760140BR0]
WOS关键词	HEAVY CHARGED-PARTICLES ; MUTATION-INDUCTION ; REPAIR CAPACITY ; ION IRRADIATION ; CELL-LINES ; BACTERIA
WOS研究方向	Instruments & Instrumentation ; Nuclear Science & Technology ; Physics
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000281498900026
资助机构	Chinese Academy of Sciences
公开日期	2011-04-20
内容类型	期刊论文
源URL	[http://ir.imp.cas.cn/handle/113462/7955]
专题	近代物理研究所_近代物理研究所知识存储（2010之前）近代物理研究所_生物物理研究室
通讯作者	Wang, Jufang
作者单位	Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China
推荐引用方式 GB/T 7714	Wang, Jufang,Lu, Dong,Wu, Xin,et al. Inactive and mutagenic effects induced by carbon beams of different LET values in a red yeast strain[J]. NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS,2010,268(17-18):2719-2723.
APA	Wang, Jufang.,Lu, Dong.,Wu, Xin.,Sun, Haining.,Ma, Shuang.,...&Li, Wenjian.(2010).Inactive and mutagenic effects induced by carbon beams of different LET values in a red yeast strain.NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS,268(17-18),2719-2723.
MLA	Wang, Jufang,et al."Inactive and mutagenic effects induced by carbon beams of different LET values in a red yeast strain".NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS 268.17-18(2010):2719-2723.