Influence of Hypericum perforatum Extract on Piglet Infected with Porcine Respiratory and Reproductive Syndrome Virus

doi:10.1016/S1671-2927(08)60272-2

CORC > 近代物理研究所 > 中国科学院近代物理研究所 > 近代物理研究所知识存储（2010之前）

	Influence of Hypericum perforatum Extract on Piglet Infected with Porcine Respiratory and Reproductive Syndrome Virus
	Wang Xue-hong 3; Liu Yu 3; Shang Ruo-feng 3; Liang Jian-ping2,3 ; Pu Xiu-ying 1,3; Wang Zuo-xin 1,3; Hua Lan-ying 3
刊名	AGRICULTURAL SCIENCES IN CHINA
	2009-06-20
卷号	8 期号:6 页码:730-739
关键词	porcine respiratory and reproductive syndrome virus (PRRSV) porcine respiratory and reproductive syndrome (PRRS) Hypericum perforatum extract (HPE) piglet
ISSN号	1671-2927
DOI	10.1016/S1671-2927(08)60272-2
英文摘要	To study the influence of Hypericum perforatum extract (HPE) on piglets infected with porcine respiratory and reproductive syndrome virus (PRRSV), enzyme-labeled immunosorbent assay (ELISA) and cytopathic effect (CPE) were used to determine in vitro whether HPE could induce swine pulmonary alveolar macrophages (PAMs) to secrete IFN-gamma, and whether PRRSV titers in PAMs were affected by the levels of HPE-induced IFN-gamma. HPE (200 mg kg(-1)) was administrated by oral gavage to piglets infected with the PRRSV in vivo to observe whether HPE affected the viremia, lung viral titers, and weight gain of piglets infected with PRRSV. The results showed that HPE was capable of inducing PAMs to produce IFN-gamma in a dose dependent manner and HPE pretreatment was capable of significantly reducing PRRSV viral titers in PAMs (P<0.01). Administration of HPE to the PRRSV-infected animals significantly (P<0.05) reduced viremia over time as compared with the PRRSV-infected animals. But there was not significant decrease in lung viral titers at day 21 post-infection between the HPE-treated animals and the PRRSV-infected control piglets. There were no significant differences in weight gain over time among the HPE-treatment animals, the normal control, and the HPE control animals. The PRRSV-infected animals caused significant (P<0.01) growth retardation as compared with the HPE controls and the normal piglets. It suggested that HPE might be an effective novel therapeutic approach to diminish the PRRSV-induced disease in swine.
资助项目	State Level Research Institutes for Public Welfare, China[BRF070402] ; Chinese Academy of Sciences[Renjiaozi [2008] 287]
WOS关键词	HUMAN-IMMUNODEFICIENCY-VIRUS ; ISOLATE ATCC VR-2332 ; INTERFERON-GAMMA ; ANTHRAQUINONE DERIVATIVES ; ALVEOLAR MACROPHAGES ; ANTIVIRAL ACTIVITY ; VIRUCIDAL ACTIVITY ; SWINE INFERTILITY ; GNOTOBIOTIC PIGS ; IMMUNE-RESPONSE
WOS研究方向	Agriculture
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000278076000014
资助机构	State Level Research Institutes for Public Welfare, China ; Chinese Academy of Sciences
公开日期	2011-04-20
内容类型	期刊论文
源URL	[http://ir.imp.cas.cn/handle/113462/7951]
专题	近代物理研究所_近代物理研究所知识存储（2010之前）近代物理研究所_重离子辐照药物研发中心
通讯作者	Liang Jian-ping
作者单位	1.Gansu Agr Univ, Coll Vet Med, Lanzhou 730070, Peoples R China 2.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China 3.Chinese Acad Agr Sci, Lanzhou Inst Anim & Vet Pharmaceut Sci, Lanzhou 730050, Peoples R China
推荐引用方式 GB/T 7714	Wang Xue-hong,Liu Yu,Shang Ruo-feng,et al. Influence of Hypericum perforatum Extract on Piglet Infected with Porcine Respiratory and Reproductive Syndrome Virus[J]. AGRICULTURAL SCIENCES IN CHINA,2009,8(6):730-739.
APA	Wang Xue-hong.,Liu Yu.,Shang Ruo-feng.,Liang Jian-ping.,Pu Xiu-ying.,...&Hua Lan-ying.(2009).Influence of Hypericum perforatum Extract on Piglet Infected with Porcine Respiratory and Reproductive Syndrome Virus.AGRICULTURAL SCIENCES IN CHINA,8(6),730-739.
MLA	Wang Xue-hong,et al."Influence of Hypericum perforatum Extract on Piglet Infected with Porcine Respiratory and Reproductive Syndrome Virus".AGRICULTURAL SCIENCES IN CHINA 8.6(2009):730-739.