Correlation between initial chromatid damage and survival of various cell lines exposed to heavy charged particles

doi:10.1007/s00411-006-0063-2

CORC > 近代物理研究所 > 中国科学院近代物理研究所 > 近代物理研究所知识存储（2010之前）

	Correlation between initial chromatid damage and survival of various cell lines exposed to heavy charged particles
	Yang Jianshe ; Jing Xigang ; Li Wenjian ; Wang Zhuanzi ; Zhou Guangming ; Wang Jufang ; Dang Bingrong ; Gao Qingxiang ; Walsh, Linda
刊名	RADIATION AND ENVIRONMENTAL BIOPHYSICS
	2006-11-01
卷号	45 期号:4 页码:261-266
ISSN号	0301-634X
DOI	10.1007/s00411-006-0063-2
英文摘要	The biophysical characteristics of heavy ions make them a rational source of radiation for use in radiotherapy of malignant tumours. Prior to radiotherapy treatment, a therapeutic regimen must be precisely defined, and during this stage information on individual patient radiosensitivity would be of very great medical value. There are various methods to predict radiosensitivity, but some shortfalls are difficult to avoid. The present study investigated the induction of chromatid breaks in five different cell lines, including one normal liver cell line (L02), exposed to carbon ions accelerated by the heavy ion research facility in Lanzhou (HIRFL), using chemically induced premature chromosome condensation (PCC). Previous studies have reported the number of chromatid breaks to be linearly related to the radiation dose, but the relationship between cell survival and chromatid breaks is not clear. The major result of the present study is that cellular radiosensitivity, as measured by D-0, is linearly correlated with the frequency of chromatid breaks per Gy in these five cell lines. We propose that PCC may be applied to predict radiosensitivity of tumour cells exposed to heavy ions.
WOS关键词	HIGH-LET RADIATION ; HUMAN FIBROBLASTS ; INTRINSIC RADIOSENSITIVITY ; CARCINOMA ; BREAKS ; CHROMOSOMES ; REPAIR ; CERVIX ; IONS
WOS研究方向	Life Sciences & Biomedicine - Other Topics ; Biophysics ; Environmental Sciences & Ecology ; Radiology, Nuclear Medicine & Medical Imaging
语种	英语
出版者	SPRINGER
WOS记录号	WOS:000242136400004
公开日期	2010-10-29
内容类型	期刊论文
源URL	[http://ir.imp.cas.cn/handle/113462/6107]
专题	近代物理研究所_近代物理研究所知识存储（2010之前）
通讯作者	Yang Jianshe
作者单位	1.Chinese Acad Sci, Lanzhou Inst Chem Phys, Inst Modern Phys, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.Lanzhou Univ, Sch Life Sci, Lanzhou 730000, Peoples R China 4.GSF, Natl Res Ctr, Inst Radiat Protect, D-85764 Neuherberg, Germany
推荐引用方式 GB/T 7714	Yang Jianshe,Jing Xigang,Li Wenjian,et al. Correlation between initial chromatid damage and survival of various cell lines exposed to heavy charged particles[J]. RADIATION AND ENVIRONMENTAL BIOPHYSICS,2006,45(4):261-266.
APA	Yang Jianshe.,Jing Xigang.,Li Wenjian.,Wang Zhuanzi.,Zhou Guangming.,...&Walsh, Linda.(2006).Correlation between initial chromatid damage and survival of various cell lines exposed to heavy charged particles.RADIATION AND ENVIRONMENTAL BIOPHYSICS,45(4),261-266.
MLA	Yang Jianshe,et al."Correlation between initial chromatid damage and survival of various cell lines exposed to heavy charged particles".RADIATION AND ENVIRONMENTAL BIOPHYSICS 45.4(2006):261-266.