A novel pencil beam model for carbon-ion dose calculation derived from Monte Carlo simulations

doi:10.1016/j.ejmp.2018.10.014

CORC > 近代物理研究所 > 中国科学院近代物理研究所 > 兰州重离子研究装置

	A novel pencil beam model for carbon-ion dose calculation derived from Monte Carlo simulations
	Zhang, Hui; Dai, Zhongying; Liu, Xinguo; Chen, Weiqiang; Ma, Yuanyuan; He, Pengbo; Dai, Tianyuan; Shen, Guosheng; Yuan, Ping; Li, Qiang
刊名	PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
	2018
卷号	55 页码:15-24
关键词	Heavy ion therapy Kernel beam model Secondary particles Low dose envelope
ISSN号	1120-1797
DOI	10.1016/j.ejmp.2018.10.014
英文摘要	An accurate kernel model is of vital importance for pencil-beam dose algorithm in charged particle therapy using precise spot-scanning beam delivery, in which an accurate depiction of the low dose envelope is especially crucial. Based on the Monte Carlo method, we investigated the dose contribution of secondary particles to the total dose and proposed a novel beam model to depict the lateral dose distribution of carbon-ion pencil beam in water. We demonstrated that the low dose envelope in single-spot profiles in water could be adequately modelled with the addition of a logistic distribution to a double Gaussian one, which was verified in both single carbon-ion pencil beam and superposed fields of different sizes with multiple pencil beams. Its superiority was mainly manifested at medium depths especially for high-energy beams with small fields compared with single, double and triple Gaussian models, where the secondary particles influenced the total dose considerably. The double Gaussian-logistic model could reduce the deviations from 4.1%, 1.7% to 0.3% in the plateau and peak regions, and from 19.2%, 4.9% to 1.2% in the tail region compared for the field size factor (FSF) calculations of 344 MeV/u carbon-ion pencil beam with the single and double Gaussian models. Compared with the triple Gaussian one, our newly-proposed model was on a par with it, even better than it in the plateau and peak regions. Thus our work will be helpful for improving the dose calculation accuracy for carbon-ion therapy.
资助项目	Youth Innovation Promotion Association of the Chinese Academy of Sciences[2015340] ; Youth Innovation Promotion Association of the Chinese Academy of Sciences[2017454]
WOS关键词	PROTON THERAPY ; SCANNED PROTON ; RADIOTHERAPY ; ALGORITHM ; INSTITUTE ; PROFILES ; SYSTEM ; GATE
WOS研究方向	Radiology, Nuclear Medicine & Medical Imaging
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000450741900003
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/59884]
专题	近代物理研究所_兰州重离子研究装置近代物理研究所_生物物理研究室中国科学院近代物理研究所
通讯作者	Li, Qiang
作者单位	Chinese Acad Sci, Inst Modern Phys, 509 Nanchang Rd, Lanzhou 73000, Gansu, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Hui,Dai, Zhongying,Liu, Xinguo,et al. A novel pencil beam model for carbon-ion dose calculation derived from Monte Carlo simulations[J]. PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS,2018,55:15-24.
APA	Zhang, Hui.,Dai, Zhongying.,Liu, Xinguo.,Chen, Weiqiang.,Ma, Yuanyuan.,...&Li, Qiang.(2018).A novel pencil beam model for carbon-ion dose calculation derived from Monte Carlo simulations.PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS,55,15-24.
MLA	Zhang, Hui,et al."A novel pencil beam model for carbon-ion dose calculation derived from Monte Carlo simulations".PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS 55(2018):15-24.