Biphasic Regulation of H2O2 on Angiogenesis and Natural Antioxidant Pedicularioside G Inhibits Angiogenesis and Tumorigenesis in vitro and in vivo

	Biphasic Regulation of H2O2 on Angiogenesis and Natural Antioxidant Pedicularioside G Inhibits Angiogenesis and Tumorigenesis in vitro and in vivo
	Zhao, B ; Mu, P.3; Liu, Q.4; Gao, X.2; Jia, Z. J.2; Zheng, R. L.1,3; Davies, M ; Cadeans, E
	2008
关键词	Pedicularioside G Angiogenesis Tumorigenesis Proliferation Migration Reactive oxygen species
页码	37-+
英文摘要	Exogenous H2O2 enhanced proliferation, migration in human umbilical vein endothelial cells (HUVECs), and vessel formation on chick embryo chorioallantoic membrane (CAM) in low concentration but inhibited in high concentration. Natural polyphenol, pedicularioside (Ped G), attenuated two prerequisite angiogenic procedures, endothelial cell proliferation and migration, as well as neovascularization in vivo. It also inhibited human hepatoma cell proliferation and migration in vitro along with tumor formation and growth in vivo. Moreover, Ped G remarkably reduced reactive oxygen species (ROS) level in both endothelial cells and hepatoma cells. Therefore, Ped G has the properties of not only anti-angiogenesis but also anti-tumor growth and anti-tumorigenesis which might partially attribute to its antioxidative activity.
会议录	PROCEEDINGS OF THE XIV BIENNIAL MEETING OF THE SOCIETY FOR FREE RADICAL RESEARCH INTERNATIONAL
会议录出版者	MEDIMOND S R L
会议录出版地	VIA MASERATI 5, 40128 BOLOGNA, 00000, ITALY
语种	英语
WOS研究方向	Biochemistry & Molecular Biology
WOS记录号	WOS:000272106600007
内容类型	会议论文
源URL	[http://119.78.100.186/handle/113462/58504]
专题	中国科学院近代物理研究所
通讯作者	Mu, P.
作者单位	1.Shanghai Univ Tradit Chinese Med, E Inst Shanghai Univ, Div Nitr Oxide & Inflammatory Med, Shanghai, Peoples R China 2.Lanzhou Univ, Sch Chem & Chem Engn, Lanzhou, Gansu, Peoples R China 3.Lanzhou Univ, Inst Biophys, Sch Life Sci, Lanzhou 730000, Gansu, Peoples R China 4.Chinese Acad Sci, Inst Modern Phys, Dept Radiol, Lanzhou, Gansu, Peoples R China
推荐引用方式 GB/T 7714	Zhao, B,Mu, P.,Liu, Q.,et al. Biphasic Regulation of H2O2 on Angiogenesis and Natural Antioxidant Pedicularioside G Inhibits Angiogenesis and Tumorigenesis in vitro and in vivo[C]. 见:.