A dynamical model of DNA-damage derived p53-Mdm2 interaction

	A dynamical model of DNA-damage derived p53-Mdm2 interaction
	Zhang Li-Juan ; Yan Shi-Wei ; Zhuo Yi-Zhong
刊名	ACTA PHYSICA SINICA
	2007-04
卷号	56 页码:2442-2447
关键词	p53-Mdm2 negative feedback loop sustained and damped oscillations nonlinear dynamical model
ISSN号	1000-3290
英文摘要	The recent experiments on the dynamics of a common biological network motif, p53-Mdm2 feedback loop in population and individual cells shows two different kinds of oscillatory behaviors, namely the damped and sustained oscillations, for the activities of p53 and Mdm2 proteins in response to DNA damage. By exploiting the nonlinear dynamics in the negative feedback loop and through analyzing the dynamical relation between the DNA damage and the activities of p53 and Mdm2 proteins, we propose a nonlinear dynamical model to describe the oscillatory behaviors for the activities of p53 and Mdm2 proteins both in individual and in population of cells in a self-consistent and unified way.
WOS关键词	FEEDBACK LOOP ; P53 ; MDM2 ; EXPRESSION ; CELLS
WOS研究方向	Physics
语种	中文
出版者	CHINESE PHYSICAL SOC
WOS记录号	WOS:000245844300097
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/56962]
专题	中国科学院近代物理研究所
通讯作者	Yan Shi-Wei
作者单位	1.Beijing Normal Univ, Inst Low Energy Nucl Phys, Beijing 100875, Peoples R China 2.Capital Normal Univ, Dept Phys, Beijing 100037, Peoples R China 3.Natl Lab Heavy Ion Accelerator Lanzhou, Lanzhou 730000, Peoples R China
推荐引用方式 GB/T 7714	Zhang Li-Juan,Yan Shi-Wei,Zhuo Yi-Zhong. A dynamical model of DNA-damage derived p53-Mdm2 interaction[J]. ACTA PHYSICA SINICA,2007,56:2442-2447.
APA	Zhang Li-Juan,Yan Shi-Wei,&Zhuo Yi-Zhong.(2007).A dynamical model of DNA-damage derived p53-Mdm2 interaction.ACTA PHYSICA SINICA,56,2442-2447.
MLA	Zhang Li-Juan,et al."A dynamical model of DNA-damage derived p53-Mdm2 interaction".ACTA PHYSICA SINICA 56(2007):2442-2447.