Intrinsic noise and Hill dynamics in the p53 system

doi:10.1016/j.jtbi.2010.10.009

	Intrinsic noise and Hill dynamics in the p53 system
	Liu, Bo 1; Yan, Shiwei 1,2,3; Wang, Qi 1
刊名	JOURNAL OF THEORETICAL BIOLOGY
	2011-01-21
卷号	269 页码:104-108
关键词	Protein circuit Modeling Noise Nonlinear analysis
ISSN号	0022-5193
DOI	10.1016/j.jtbi.2010.10.009
英文摘要	The p53 feedback loop can induce cellular senescence, cell cycle arrest and apoptosis in response to various stresses, including DNA damage, hypoxia and nutrient deprivation. Using a stochastic model of the negative feedback circuit involving p53 and its inhibitor Mdm2, we present the different oscillatory dynamics at the single-cell and population-cell levels as described in the experiments, and the resonant nature of the oscillations is captured. The stationary distributions of protein populations are characterized by non-Gaussian nature which is due to the interplay between time delay and nonlinearity of reactions. (C) 2010 Elsevier Ltd. All rights reserved.
资助项目	Scientific Research Foundation for the Returned Overseas Chinese Scholars, Ministry of Personnel of China[MOP2006138]
WOS关键词	P53-MDM2 FEEDBACK LOOP ; DNA-DAMAGE ; OSCILLATIONS ; MODEL ; NETWORK ; PULSES ; CELLS ; MDM2 ; BISTABILITY ; SIMULATION
WOS研究方向	Life Sciences & Biomedicine - Other Topics ; Mathematical & Computational Biology
语种	英语
出版者	ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
WOS记录号	WOS:000286173000011
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/56961]
专题	中国科学院近代物理研究所
通讯作者	Yan, Shiwei
作者单位	1.Beijing Normal Univ, Coll Nucl Sci & Technol, Beijing 100875, Peoples R China 2.Beijing Radiat Ctr, Beijing 100875, Peoples R China 3.Ctr Theoret Phys, Natl Lab Heavy Ion Accelerator Lanzhou, Lanzhou 730000, Peoples R China
推荐引用方式 GB/T 7714	Liu, Bo,Yan, Shiwei,Wang, Qi. Intrinsic noise and Hill dynamics in the p53 system[J]. JOURNAL OF THEORETICAL BIOLOGY,2011,269:104-108.
APA	Liu, Bo,Yan, Shiwei,&Wang, Qi.(2011).Intrinsic noise and Hill dynamics in the p53 system.JOURNAL OF THEORETICAL BIOLOGY,269,104-108.
MLA	Liu, Bo,et al."Intrinsic noise and Hill dynamics in the p53 system".JOURNAL OF THEORETICAL BIOLOGY 269(2011):104-108.