Differential Proteomics Reveals the Potential Injury Mechanism Induced by Heavy Ion Radiation in Mice Ovaries

doi:10.3967/bes2017.040

	Differential Proteomics Reveals the Potential Injury Mechanism Induced by Heavy Ion Radiation in Mice Ovaries
	He Yu Xuan 1; Zhang Hong2,3,4 ; Li Hong Yan 2,3,4; Zhang Yong 1; Jia Qi Peng 1; Li Zong Shuai 1; Zhao Xing Xu 1
刊名	BIOMEDICAL AND ENVIRONMENTAL SCIENCES
	2017-04-01
卷号	30 页码:301-307
ISSN号	0895-3988
DOI	10.3967/bes2017.040
英文摘要	In the present study, we used a proteomics approach based on a two-dimensional electrophoresis (2-DE) reference map to investigate protein expression in the ovarian tissues of pubertal Swiss-Webster mice subjected to carbon ion radiation (CIR). Among the identified proteins, ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) is associated with the cell cycle([1]) and that it influences proliferation in ovarian tissues. We analyzed the expression of UCH-L1 and the proliferation marker proliferation cell nuclear antigen (PCNA) following CIR using immunoblotting and immunofluorescence. The proteomics and biochemical results provide insight into the underlying mechanisms of CIR toxicity in ovarian tissues.
资助项目	Fostering Foundation[2013002] ; National High Technology Research and Development Program of China[2013AA102505] ; Ministry of Science and Technology National Key RD project[2016YFC0904600]
WOS关键词	TERMINAL HYDROLASE L1
WOS研究方向	Environmental Sciences & Ecology ; Public, Environmental & Occupational Health
语种	英语
出版者	CHINESE CENTER DISEASE CONTROL & PREVENTION
WOS记录号	WOS:000407000500008
资助机构	Fostering Foundation ; National High Technology Research and Development Program of China ; Ministry of Science and Technology National Key RD project
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/45473]
专题	中国科学院近代物理研究所
通讯作者	Zhao Xing Xu
作者单位	1.Gansu Agr Univ, Coll Vet Med, Lanzhou 730070, Gansu, Peoples R China 2.Chinese Acad Sci, Inst Modern Phys, Dept Radiat Med, Lanzhou 730000, Gansu, Peoples R China 3.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Gansu, Peoples R China 4.Key Lab Basic Res Heavy Ion Radiat Applicat Med, Lanzhou 730000, Gansu, Peoples R China
推荐引用方式 GB/T 7714	He Yu Xuan,Zhang Hong,Li Hong Yan,et al. Differential Proteomics Reveals the Potential Injury Mechanism Induced by Heavy Ion Radiation in Mice Ovaries[J]. BIOMEDICAL AND ENVIRONMENTAL SCIENCES,2017,30:301-307.
APA	He Yu Xuan.,Zhang Hong.,Li Hong Yan.,Zhang Yong.,Jia Qi Peng.,...&Zhao Xing Xu.(2017).Differential Proteomics Reveals the Potential Injury Mechanism Induced by Heavy Ion Radiation in Mice Ovaries.BIOMEDICAL AND ENVIRONMENTAL SCIENCES,30,301-307.
MLA	He Yu Xuan,et al."Differential Proteomics Reveals the Potential Injury Mechanism Induced by Heavy Ion Radiation in Mice Ovaries".BIOMEDICAL AND ENVIRONMENTAL SCIENCES 30(2017):301-307.