Influences of pH and Iron Concentration on the Salivary Microbiome in Individual Humans with and without Caries

doi:10.1128/AEM.02412-16

	Influences of pH and Iron Concentration on the Salivary Microbiome in Individual Humans with and without Caries
	Zhou, Jianye 1; Jiang, Nan 2; Wang, Zhenzhen 3; Li, Longqing 4; Zhang, Jumei 1; Ma, Rui 3; Nie, Hongbing 1; Li, Zhiqiang 1
刊名	APPLIED AND ENVIRONMENTAL MICROBIOLOGY
	2017-02-01
卷号	83 页码:12
关键词	caries iron microbial communities pH saliva
ISSN号	0099-2240
DOI	10.1128/AEM.02412-16
英文摘要	This study aimed to identify the differences in the oral microbial communities in saliva from patients with and without caries by performing sequencing with the Illumina MiSeq platform, as well as to further assess their relationships with environmental factors (salivary pH and iron concentration). Forty-three volunteers were selected, including 21 subjects with and 22 without caries, from one village in Gansu, China. Based on 966,255 trimmed sequences and clustering at the 97% similarity level, 1,303 species-level operational taxonomic units were generated. The sequencing data for the two groups revealed that (i) particular distribution patterns (synergistic effects or competition) existed in the subjects with and without caries at both the genus and species levels and (ii) both the salivary pH and iron concentration had significant influences on the microbial community structure. IMPORTANCE The significant influences of the oral environment observed in this study increase the current understanding of the salivary microbiome in caries. These results will be useful for expanding research directions and for improving disease diagnosis, prognosis, and therapy.
资助项目	National Natural Science Fund[31360124/C0309] ; National Natural Science Fund[31560159/C0309] ; Special International Technology Cooperation of Gansu Province[144WCGA167]
WOS关键词	IN-VITRO ; DENTAL-CARIES ; ENAMEL DEMINERALIZATION ; SUBGINGIVAL MICROBIOTA ; ACID DEMINERALIZATION ; COMMUNITY COMPOSITION ; BOVINE ENAMEL ; BIOFILM ; BACTERIA ; HEALTH
WOS研究方向	Biotechnology & Applied Microbiology ; Microbiology
语种	英语
出版者	AMER SOC MICROBIOLOGY
WOS记录号	WOS:000393482200002
资助机构	National Natural Science Fund ; Special International Technology Cooperation of Gansu Province
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/44304]
专题	中国科学院近代物理研究所
通讯作者	Li, Zhiqiang
作者单位	1.Northwest Univ Nationalities, Key Lab Oral Dis Gansu Prov, Key Lab Stomatol State Ethn Affairs Commiss, Lanzhou, Gansu, Peoples R China 2.Chinese Acad Sci, Inst Appl Ecol, Shenyang, Peoples R China 3.Lanzhou Univ, Sch Stomatol, Lanzhou, Peoples R China 4.Chinese Acad Sci, Inst Modern Phys, Lanzhou, Peoples R China
推荐引用方式 GB/T 7714	Zhou, Jianye,Jiang, Nan,Wang, Zhenzhen,et al. Influences of pH and Iron Concentration on the Salivary Microbiome in Individual Humans with and without Caries[J]. APPLIED AND ENVIRONMENTAL MICROBIOLOGY,2017,83:12.
APA	Zhou, Jianye.,Jiang, Nan.,Wang, Zhenzhen.,Li, Longqing.,Zhang, Jumei.,...&Li, Zhiqiang.(2017).Influences of pH and Iron Concentration on the Salivary Microbiome in Individual Humans with and without Caries.APPLIED AND ENVIRONMENTAL MICROBIOLOGY,83,12.
MLA	Zhou, Jianye,et al."Influences of pH and Iron Concentration on the Salivary Microbiome in Individual Humans with and without Caries".APPLIED AND ENVIRONMENTAL MICROBIOLOGY 83(2017):12.