Characterization of novel cyclic lipopeptides produced by Bacillus sp. SY27F | |
Zhou, Hong1; Cong, Bailin2; Tian, Yongqi1; He, Yu3; Yang, Huanghao3 | |
刊名 | PROCESS BIOCHEMISTRY |
2019-08 | |
卷号 | 83页码:206-213 |
关键词 | Deep-sea hydrothermal vent Cyclic lipopeptides Bacillus Bioactivity |
ISSN号 | 1359-5113 |
DOI | 10.1016/j.procbio.2019.04.015 |
英文摘要 | Three new cyclic lipopeptides (compounds 1-3) were isolated from Bacillus sp. SY27F, which collected from the deep-sea hydrothermal vent in the Indian Ocean. The planar structures of compounds 1-3 were characterized by LC-MS, GC-MS and NMR, whereas their absolute configurations were determined by modified Marfey's analysis and optical rotation contrast. They shared the same heptapeptide chain (N-L-Gln(1)-D-Leu(2)-L-Leu(3)-L-Val(4)-L-Asp(5)-D-Leu(6)-L-Ile(7)-C), differing only by the length of the fatty acid chain. Compounds 1-3 displayed significant cytotoxic activity against DU145, MCF-7 and HepG2 cancer cell lines with IC50 values of 96.8-190.7 nM and moderate to weak cytotoxicity against A549, HeLa and HT1080, with IC50 values of 9.3-43.2 mu M, respectively. However, none of the three compounds showed any antibacterial activity against Escherichia coli, Staphylococcus aureus and Monilia albicans. |
资助项目 | Scientific and Technological Project of Fuzhou City of Fujian Province[2017-N-39] |
WOS研究方向 | Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Engineering |
语种 | 英语 |
出版者 | ELSEVIER SCI LTD |
WOS记录号 | WOS:000474502600024 |
内容类型 | 期刊论文 |
源URL | [http://ir.fio.com.cn:8080/handle/2SI8HI0U/27664] |
专题 | 业务部门_海洋生态研究中心 |
通讯作者 | Cong, Bailin; Tian, Yongqi |
作者单位 | 1.Fuzhou Univ, Coll Biol Sci & Engn, Fuzhou 350116, Fujian, Peoples R China 2.State Ocean Adm, Inst Oceanog 1, Qingdao 266061, Shandong, Peoples R China 3.Fuzhou Univ, State Key Lab Photocatalysis Energy & Environm, MOE Key Lab Analyt Sci Food Safety & Biol, Coll Chem, Fuzhou 350116, Fujian, Peoples R China |
推荐引用方式 GB/T 7714 | Zhou, Hong,Cong, Bailin,Tian, Yongqi,et al. Characterization of novel cyclic lipopeptides produced by Bacillus sp. SY27F[J]. PROCESS BIOCHEMISTRY,2019,83:206-213. |
APA | Zhou, Hong,Cong, Bailin,Tian, Yongqi,He, Yu,&Yang, Huanghao.(2019).Characterization of novel cyclic lipopeptides produced by Bacillus sp. SY27F.PROCESS BIOCHEMISTRY,83,206-213. |
MLA | Zhou, Hong,et al."Characterization of novel cyclic lipopeptides produced by Bacillus sp. SY27F".PROCESS BIOCHEMISTRY 83(2019):206-213. |
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