Yessotoxin induces apoptosis in HL7702 human liver cells

doi:10.3892/mmr.2011.606

CORC > 自然资源部第一海洋研究所 > 自然资源部第一海洋研究所 > 业务部门 > 海洋生态研究中心

	Yessotoxin induces apoptosis in HL7702 human liver cells
	Pang, Min 1; Qu, Pei 2; Gao, Chun-Lei 1; Wang, Zong-Ling 1
刊名	MOLECULAR MEDICINE REPORTS
	2012-01
卷号	5 期号:1 页码:211-216
关键词	yessotoxin apoptosis HL7702 cells mitochondrial transmembrane potential calcium level
ISSN号	1791-2997
DOI	10.3892/mmr.2011.606
英文摘要	The marine toxin yessotoxin (YTX) is found in numerous aquatic environments and poses a potential threat to the shellfish industry and to public health. We analyzed the toxicity of YTX on HL7702 human liver cells using optical microscopy, Hoechst 33342 chromatin staining, DNA gel electrophoresis, rhodamine 123 staining and calcium-sensitive laser scanning confocal microscopy. The results demonstrated that YTX induced the usual hallmarks of apoptosis, including chromain condensation. DNA laddering, activity of caspase-3 deregulation and loss of mitochondrial membrane potential. Furthermore, YTX caused cytosolic calcium levels to increase in HL7702 cells. YTX may cause liver damage through hepatocyte apoptosis.
URL标识	查看原文
资助项目	First Institute of Oceanography, SOA[2011T07]
WOS研究方向	Oncology ; Research & Experimental Medicine
语种	英语
出版者	SPANDIDOS PUBL LTD
WOS记录号	WOS:000297486700038
内容类型	期刊论文
源URL	[http://ir.fio.com.cn/handle/2SI8HI0U/4150]
专题	业务部门_海洋生态研究中心
作者单位	1.State Ocean Adm, Inst Oceanog 1, Qingdao 266061, Peoples R China; 2.Ocean Univ China, Coll Environm Sci & Engn, Qingdao 266100, Peoples R China
推荐引用方式 GB/T 7714	Pang, Min,Qu, Pei,Gao, Chun-Lei,et al. Yessotoxin induces apoptosis in HL7702 human liver cells[J]. MOLECULAR MEDICINE REPORTS,2012,5(1):211-216.
APA	Pang, Min,Qu, Pei,Gao, Chun-Lei,&Wang, Zong-Ling.(2012).Yessotoxin induces apoptosis in HL7702 human liver cells.MOLECULAR MEDICINE REPORTS,5(1),211-216.
MLA	Pang, Min,et al."Yessotoxin induces apoptosis in HL7702 human liver cells".MOLECULAR MEDICINE REPORTS 5.1(2012):211-216.