Development of a High Performance Liquid Chromatography-Tandem Mass Spectrometry Method for Determination of Lipophilic Toxins in Marine Shellfishes and Edible Safety Evaluation

doi:10.1016/S1872-2040(18)61092-8

	Development of a High Performance Liquid Chromatography-Tandem Mass Spectrometry Method for Determination of Lipophilic Toxins in Marine Shellfishes and Edible Safety Evaluation
	Shen Hui-Hui 1,2; Chen Jun-Hui 2,3; Xu Xiu-Li 1; Pan Lei 2; He Xiu-Ping 2; Wang Xiao-Ru 2,3
刊名	CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
	2018-06
卷号	46 期号:6 页码:985-992
关键词	Liquid chromatography-tandem mass spectrometry Marine shellfishes Lipophilic shellfish toxins Combined contamination Food safety
ISSN号	0253-3820
DOI	10.1016/S1872-2040(18)61092-8
英文摘要	At present, edible marine shellfishes are often contaminated by a combination of different kinds of marine lipophilic toxins. In this study, several common lipophilic shellfish toxins (LSTs) in marine shellfishes were simultaneously detected by liquid chromatography-tandem mass spectrometry, and the safety risk of commercial marine shellfishes was evaluated based on the materiome of LSTs. Under the optimal conditions, the developed method displayed satisfactory recovery values (63.2%-88.8%), precision (relative standard deviations <= 14.5%), and sensitivity (limit of detection in the range of 0.54-2.69 ng g(-1)) for all analytes. Among the 105 commercially available shellfish samples, 42.86% of the samples had at least one kind of toxins. The highest average content was 47.60 mu g kg(-1) of DTX1, which was the most serious contaminant in marine shellfish samples. Total Exposure Risk Index (Sigma ERI) was calculated based on Total Daily Intake (TDI) and Acute Reference Dose (ARfD) of each toxin to evaluate the safety risk of commercial marine shellfishes. The results indicated that the risk of toxin poisoning was 19.05% in the commercial available marine shellfishes, and the scallops (Chlamys farreri) have the highest poisoning risk among different shellfishes used in this study. In summary, a new method based on the combined contamination of LSTs was successfully developed for the risk assessment of commercial marine shellfishes. The proposed method is stricter than that in the relevant rules of European Food Safety Authority (EFSA) and can benefit to protect shellfish consumers from poisoning risk.
资助项目	National Natural Science Foundation of China-Shandong[U1706217] ; National Natural Science Foundation of China-Shandong[U1606404]
WOS关键词	CHINA ; EXTRACTION ; SEAWATER
WOS研究方向	Chemistry
语种	英语
出版者	ELSEVIER SCIENCE INC
WOS记录号	WOS:000438469800006
内容类型	期刊论文
源URL	[http://ir.fio.com.cn:8080/handle/2SI8HI0U/26725]
专题	自然资源部第一海洋研究所
通讯作者	Chen Jun-Hui
作者单位	1.China Univ Geosci, Sch Ocean Sci, Beijing 100083, Peoples R China 2.State Ocean Adm, Inst Oceanog 1, Res Ctr Marine Ecol, Qingdao 266061, Peoples R China 3.Xiamen Huaxia Univ, Xiamen 361024, Peoples R China
推荐引用方式 GB/T 7714	Shen Hui-Hui,Chen Jun-Hui,Xu Xiu-Li,et al. Development of a High Performance Liquid Chromatography-Tandem Mass Spectrometry Method for Determination of Lipophilic Toxins in Marine Shellfishes and Edible Safety Evaluation[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2018,46(6):985-992.
APA	Shen Hui-Hui,Chen Jun-Hui,Xu Xiu-Li,Pan Lei,He Xiu-Ping,&Wang Xiao-Ru.(2018).Development of a High Performance Liquid Chromatography-Tandem Mass Spectrometry Method for Determination of Lipophilic Toxins in Marine Shellfishes and Edible Safety Evaluation.CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,46(6),985-992.
MLA	Shen Hui-Hui,et al."Development of a High Performance Liquid Chromatography-Tandem Mass Spectrometry Method for Determination of Lipophilic Toxins in Marine Shellfishes and Edible Safety Evaluation".CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 46.6(2018):985-992.