Polymer monolithic capillary column fabricated by using monodisperse iron oxide nanocrystal template to enhance the electrochromatographic separation of small molecules

doi:10.1002/elps.201300647

	Polymer monolithic capillary column fabricated by using monodisperse iron oxide nanocrystal template to enhance the electrochromatographic separation of small molecules
	Lin, Zian 1; Wang, Juan 1; Yin, Xiaofei 2; Tan, Xiaoqing 1; Yu, Ruifang 1; Zheng, Jiangnan 1; Zhang, Lan 1; Chen, Guonan 1
刊名	ELECTROPHORESIS
	2014-07
卷号	35 期号:14 页码:1947-1955
关键词	Capillary electrochromatography Iron oxide nanocrystals Polymer monolith Small molecules
ISSN号	0173-0835
DOI	10.1002/elps.201300647
英文摘要	Monodisperse iron oxide nanocrystals and organic solvents were utilized as coporogens in monolithic poly(glycidylmethacrylate-co-ethylene glycol dimethacrylate) capillary columns to afford stationary phases with enhanced electrochromatographic performance of small molecules. While the conventional monoliths using organic solvents only as a porogen exhibited poor resolution (Rs) <1.0 and low efficiency of 40 000-60 000 plates/m, addition of a small amount of nanocrystals to the polymerization mixture provided increased resolution (Rs > 3.0) and high efficiency ranged from 60 000 to 100 000 plates/m at the same linear velocity of 0.856 mm/s. It was considered that the mesopores introduced by the nanocrystals played an important role in the improvement of the monolith performance. This new strategy expanded the application range of the hydrophobic monoliths in the separation of polar alkaloids and narcotics. The successful applications demonstrated that the glycidyl methacrylate based monoliths prepared by using nanocrystal template are a good alternative for enhanced separation efficiency of small molecules.
资助项目	Program for Changjiang Scholars and Innovative Research Team in University[IRT1116]
WOS关键词	LIQUID-CHROMATOGRAPHY ; GOLD NANOPARTICLES ; PROTEINS ; PEPTIDES ; FUNCTIONALITIES ; PRESSURE ; SIZE ; CO
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
语种	英语
出版者	WILEY-BLACKWELL
WOS记录号	WOS:000339661300003
内容类型	期刊论文
源URL	[http://ir.fio.com.cn:8080/handle/2SI8HI0U/25847]
专题	自然资源部第一海洋研究所
通讯作者	Lin, Zian
作者单位	1.Fuzhou Univ, Fujian Prov Key Lab Anal & Detect Technol Food Sa, Key Lab Anal & Detect Food Safety, Minist Educ,Coll Chem, Fuzhou 350116, Fujian, Peoples R China 2.SOA, Inst Oceanog 1, Qingdao, Peoples R China
推荐引用方式 GB/T 7714	Lin, Zian,Wang, Juan,Yin, Xiaofei,et al. Polymer monolithic capillary column fabricated by using monodisperse iron oxide nanocrystal template to enhance the electrochromatographic separation of small molecules[J]. ELECTROPHORESIS,2014,35(14):1947-1955.
APA	Lin, Zian.,Wang, Juan.,Yin, Xiaofei.,Tan, Xiaoqing.,Yu, Ruifang.,...&Chen, Guonan.(2014).Polymer monolithic capillary column fabricated by using monodisperse iron oxide nanocrystal template to enhance the electrochromatographic separation of small molecules.ELECTROPHORESIS,35(14),1947-1955.
MLA	Lin, Zian,et al."Polymer monolithic capillary column fabricated by using monodisperse iron oxide nanocrystal template to enhance the electrochromatographic separation of small molecules".ELECTROPHORESIS 35.14(2014):1947-1955.