Polycyclic Macrolactams Generated via Intramolecular Diels-Alder Reactions from an Antarctic Streptomyces Species

doi:10.1021/acs.orglett.9b01710

	Polycyclic Macrolactams Generated via Intramolecular Diels-Alder Reactions from an Antarctic Streptomyces Species
	Shen, Jingjing 1; Fan, Yaqin 1; Zhu, Guoliang 1; Chen, Hao 3; Zhu, Weiming 1,2; Fu, Peng 1,2
刊名	ORGANIC LETTERS
	2019-06-21
卷号	21 期号:12 页码:4816-4820
ISSN号	1523-7060
DOI	10.1021/acs.orglett.9b01710
英文摘要	Three new polycyclic macrolactams, cyclamenols B-D (1-3), together with a known macrolactam, cyclamenol A (4), were isolated from the Streptomyces sp. OUCMDZ-4348. Their structures including absolute configurations were determined on the basis of spectroscopic analysis, chemical methods, and ECD calculations. The biosynthetic pathways involving intramolecular Diels-Alder reactions were proposed. Compound 1 exhibited selective inhibition against the gastric carcinoma cell line N87 with an IC50 value of 10.8 mu M.
资助项目	Fundamental Research Funds for the Central Universities[201841006]
WOS关键词	ABSOLUTE-CONFIGURATIONS ; INDOLOCARBAZOLES ; BIOSYNTHESIS ; INSIGHTS ; STRAIN
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000473116000089
内容类型	期刊论文
源URL	[http://ir.fio.com.cn:8080/handle/2SI8HI0U/24569]
专题	自然资源部第一海洋研究所
通讯作者	Zhu, Weiming; Fu, Peng
作者单位	1.Ocean Univ China, Sch Med & Pharm, Minist Educ China, Key Lab Marine Drugs, Qingdao 266003, Peoples R China 2.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Drugs & Bioprod, Qingdao 266003, Peoples R China 3.Minist Nat Resources China, Inst Oceanog 1, Key Lab Marine Bioact Subst, Qingdao 266061, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Shen, Jingjing,Fan, Yaqin,Zhu, Guoliang,et al. Polycyclic Macrolactams Generated via Intramolecular Diels-Alder Reactions from an Antarctic Streptomyces Species[J]. ORGANIC LETTERS,2019,21(12):4816-4820.
APA	Shen, Jingjing,Fan, Yaqin,Zhu, Guoliang,Chen, Hao,Zhu, Weiming,&Fu, Peng.(2019).Polycyclic Macrolactams Generated via Intramolecular Diels-Alder Reactions from an Antarctic Streptomyces Species.ORGANIC LETTERS,21(12),4816-4820.
MLA	Shen, Jingjing,et al."Polycyclic Macrolactams Generated via Intramolecular Diels-Alder Reactions from an Antarctic Streptomyces Species".ORGANIC LETTERS 21.12(2019):4816-4820.