Paradigm Shift in Bioinorganic Chemistry: Enzymatic Polycondensation;Reaction of Silica in Siliceous Sponges

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	Paradigm Shift in Bioinorganic Chemistry: Enzymatic Polycondensation;Reaction of Silica in Siliceous Sponges
	Wang Xiaohong 3; Gan Lu ; Schroeder, Heinz C.; Mueller, Werner E. G.
刊名	PROGRESS IN CHEMISTRY
	2013
卷号	25 期号:4;SI SI 页码:435-445
关键词	paradigm shift bioinorganic chemistry sponges silicatein bio-silica structural hierarchies
ISSN号	1005-281X
英文摘要	The discovery of silicatein caused a paradigm shift, since it is the first enzyme which catalyzes the synthesis of a polymeric inorganic molecule from inorganic monomers. Molecular biological, biochemical and cell-biological data showed that the synthesis of siliceous spicules in both demosponges and hexactinellids is enzymatically driven via silicatein. This enzyme exists both intra-spicularly and in the extra-spicular space. It catalyzes the formation of bio-silica constituting the silica lamellae that are formed during the appositional (layer-by-layer) growth of the spicules. The extent of (bio-silica forming) activity of silicatein from the demosponge Suberites domuncula measured in vitro reflects the amount of bio-silica required for the formation of spicules in vivo. It is furthermore summarized that during growth and maturation of the spicules in demosponges a bio-fusion process occurs that results in an intra-spicular sintering of the silica lamellae to form compact silica rods. Finally we report that for the formation of the strong and stiff bio-silica skeleton of sponges a hardening process is required that is (presumably) driven by cell-membrane bound aquaporin channels which allow the removal of water, which is released during the bio-silica polycondensation reaction.
学科主题	其它
WOS关键词	SUBERITES-DOMUNCULA ; GEODIA-CYDONIUM ; BIO-SILICA ; IN-VITRO ; SPICULES ; EXPRESSION ; CATHEPSIN ; ALPHA ; PURIFICATION ; MONORHAPHIS
WOS研究方向	Chemistry
语种	英语
出版者	CHINESE ACAD SCIENCES
WOS记录号	WOS:000318131600002
内容类型	期刊论文
源URL	[http://119.78.100.197/handle/2HKVOGP0/40059]
专题	中国地质科学院国家地质实验测试中心
作者单位	1.Chinese Acad Geol Sci, Natl Res Ctr Geoanal, Beijing 100037, Peoples R China. 2.Wang Xiaohong; Schroeder, Heinz C.; Mueller, Werner E. G.] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Physiol Chem, ERC Adv Investigator Grant Res Grp, D-55128 Mainz, Germany. 3.中国地质科学院国家地质实验测试中心
推荐引用方式 GB/T 7714	Wang Xiaohong,Gan Lu,Schroeder, Heinz C.,et al. Paradigm Shift in Bioinorganic Chemistry: Enzymatic Polycondensation;Reaction of Silica in Siliceous Sponges[J]. PROGRESS IN CHEMISTRY,2013,25(4;SI SI):435-445.
APA	Wang Xiaohong,Gan Lu,Schroeder, Heinz C.,&Mueller, Werner E. G..(2013).Paradigm Shift in Bioinorganic Chemistry: Enzymatic Polycondensation;Reaction of Silica in Siliceous Sponges.PROGRESS IN CHEMISTRY,25(4;SI SI),435-445.
MLA	Wang Xiaohong,et al."Paradigm Shift in Bioinorganic Chemistry: Enzymatic Polycondensation;Reaction of Silica in Siliceous Sponges".PROGRESS IN CHEMISTRY 25.4;SI SI(2013):435-445.