Hydroxysafflor Yellow A Protects Neurons From Excitotoxic Death through Inhibition of NMDARs

doi:10.1177/1759091416642345

CORC > 上海财经大学 > 上海财经大学

	Hydroxysafflor Yellow A Protects Neurons From Excitotoxic Death through Inhibition of NMDARs
	Wang, Xingtao 1,2,3; Ma, Zhiyuan 4; Fu, Zhongxiao 5; Gao, Su 3; Yang, Liu 1,2; Jin, Yan 5; Sun, Hui 1,2; Wang, Chaoyun 6; Fan, Weiming 3; Chen, Lin 5
刊名	ASN NEURO
	2016-03-01
卷号	8 期号:2
关键词	hydroxysafflor yellow A Ca2+ imaging NMDA receptor oxygen-glucose deprivation whole-cell patch-clamp recording
ISSN号	1759-0914
DOI	10.1177/1759091416642345
英文摘要	Excessive glutamate release causes overactivation of N-methyl D-aspartate receptors (NMDARs), leading to excitatory neuronal damage in cerebral ischemia. Hydroxysafflor yellow A (HSYA), a compound extracted from Carthamus tinctorius L., has been reported to exert a neuroprotective effect in many pathological conditions, including brain ischemia. However, the underlying mechanism of HSYA's effect on neurons remains elusive. In the present study, we conducted experiments using patch-clamp recording of mouse hippocampal slices. In addition, we performed Ca2+ imaging, Western blots, as well as mitochondrial-targeted circularly permuted yellow fluorescent protein transfection into cultured hippocampal neurons in order to decipher the physiological mechanism underlying HSYA's neuroprotective effect.
WOS研究方向	Neurosciences & Neurology
语种	英语
出版者	SAGE PUBLICATIONS LTD
WOS记录号	WOS:000376771200003
内容类型	期刊论文
源URL	[http://10.2.47.112/handle/2XS4QKH4/1326]
专题	上海财经大学
通讯作者	Ma, Chun-Lei
作者单位	1.Binzhou Med Univ, Dept Physiol, Yantai, Shandong, Peoples R China; 2.Binzhou Med Univ, Brain Stroke Key Lab, Shandong Hlth Adm Inst, Yantai, Shandong, Peoples R China; 3.Binzhou Med Univ, Affiliated Hosp, Dept Internal Neurol, Binzhou, Shandong, Peoples R China; 4.Shanghai Univ Finance & Econ, Sch Publ Econ & Adm, Shanghai, Peoples R China; 5.Univ Sci & Technol China, Sch Life Sci, CAS Key Lab Brain Funct & Dis, Hefei 230026, Anhui, Peoples R China; 6.Binzhou Med Univ, Dept Pharmacol, Yantai, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Wang, Xingtao,Ma, Zhiyuan,Fu, Zhongxiao,et al. Hydroxysafflor Yellow A Protects Neurons From Excitotoxic Death through Inhibition of NMDARs[J]. ASN NEURO,2016,8(2).
APA	Wang, Xingtao.,Ma, Zhiyuan.,Fu, Zhongxiao.,Gao, Su.,Yang, Liu.,...&Ma, Chun-Lei.(2016).Hydroxysafflor Yellow A Protects Neurons From Excitotoxic Death through Inhibition of NMDARs.ASN NEURO,8(2).
MLA	Wang, Xingtao,et al."Hydroxysafflor Yellow A Protects Neurons From Excitotoxic Death through Inhibition of NMDARs".ASN NEURO 8.2(2016).