Histopathological Imaging-Environment Interactions in Cancer Modeling

doi:10.3390/cancers11040579

CORC > 上海财经大学 > 上海财经大学

	Histopathological Imaging-Environment Interactions in Cancer Modeling
	Xu, Yaqing 1; Zhong, Tingyan 2; Wu, Mengyun 3; Ma, Shuangge 1
刊名	CANCERS
	2019-04
卷号	11 期号:4
关键词	cancer modeling interaction histopathological imaging clinical environmental factors
ISSN号	2072-6694
DOI	10.3390/cancers11040579
英文摘要	Histopathological imaging has been routinely conducted in cancer diagnosis and recently used for modeling other cancer outcomes/phenotypes such as prognosis. Clinical/environmental factors have long been extensively used in cancer modeling. However, there is still a lack of study exploring possible interactions of histopathological imaging features and clinical/environmental risk factors in cancer modeling. In this article, we explore such a possibility and conduct both marginal and joint interaction analysis. Novel statistical methods, which are "borrowed" from gene-environment interaction analysis, are employed. Analysis of The Cancer Genome Atlas (TCGA) lung adenocarcinoma (LUAD) data is conducted. More specifically, we examine a biomarker of lung function as well as overall survival. Possible interaction effects are identified. Overall, this study can suggest an alternative way of cancer modeling that innovatively combines histopathological imaging and clinical/environmental data.
WOS研究方向	Oncology
语种	英语
出版者	MDPI
WOS记录号	WOS:000467773400147
内容类型	期刊论文
源URL	[http://10.2.47.112/handle/2XS4QKH4/296]
专题	上海财经大学
作者单位	1.Yale Univ, Dept Biostat, New Haven, CT 06520 USA; 2.Shanghai Jiao Tong Univ, SJTU Yale Joint Ctr Biostat, Sch Life Sci & Biotechnol, Dept Bioinformat & Biostat, Shanghai 200240, Peoples R China; 3.Shanghai Univ Finance & Econ, Sch Stat & Management, Shanghai 200433, Peoples R China
推荐引用方式 GB/T 7714	Xu, Yaqing,Zhong, Tingyan,Wu, Mengyun,et al. Histopathological Imaging-Environment Interactions in Cancer Modeling[J]. CANCERS,2019,11(4).
APA	Xu, Yaqing,Zhong, Tingyan,Wu, Mengyun,&Ma, Shuangge.(2019).Histopathological Imaging-Environment Interactions in Cancer Modeling.CANCERS,11(4).
MLA	Xu, Yaqing,et al."Histopathological Imaging-Environment Interactions in Cancer Modeling".CANCERS 11.4(2019).