Overcoming foreign-body reaction through nanotopography:   Biocompatibility and immunoisolation properties of a nanofibrous   membrane

doi:10.1016/j.biomaterials.2016.06.028

CORC > 北京大学 > 工学院

	Overcoming foreign-body reaction through nanotopography: Biocompatibility and immunoisolation properties of a nanofibrous membrane
	Wang, Kai ; Hou, Wen-Da ; Wang, Xi ; Han, Chengsheng ; Vuletic, Ivan ; Su, Ni ; Zhang, Wen-Xi ; Ren, Qiu-Shi ; Chen, Liangyi ; Luo, Ying
刊名	BIOMATERIALS
	2016
关键词	Macroencapsulation Foreign body response Cell transplantation Electrospun membrane Nanofiber MESENCHYMAL STEM-CELLS MACROPHAGE PHENOTYPE MECHANICAL-PROPERTIES POLYMER FIBERS POLARIZATION SCAFFOLDS PRIMATES ISLETS MICE NEOVASCULARIZATION
DOI	10.1016/j.biomaterials.2016.06.028
英文摘要	Implantable immunoisolation membranes need to possess superior biocompatibility to prohibit the fibrotic deposition that would reduce the nutrient supply and impair the viability/function of the encapsulated cells. Here, electrospun membranes based on thermoplastic polyurethane (TPU) were fabricated to contain microfibers (PU-micro) or nanofibers (PU-nano). The two types of membranes were compared in terms of their interaction with macrophage cells and the host tissues. It was found that the fibrous membranes of different topographies possess distinct material properties: PU-nano caused minimal macrophage responses in vitro and in vivo and induced only mild foreign body reactions compared to PU-micro membranes. A flat macroencapsulation device was fabricated using PU-nano membranes and its immunoisolation function investigated in subcutaneous transplantation models. The nanofibrous device demonstrated the capability to effectively shield the allografts from the immune attack of the host. Nanotopography may confer biocompatibility to materials and nanofibrous materials warrant further study for development of "invisible" immunoisolation devices for cell transplantation. (C) 2016 Elsevier Ltd. All rights reserved.; National Natural Science Foundation of China [31322021]; SCI(E); EI; PubMed; ARTICLE; ying.luo@pku.edu.cn; 249-258; 102
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/493605]
专题	工学院
推荐引用方式 GB/T 7714	Wang, Kai,Hou, Wen-Da,Wang, Xi,et al. Overcoming foreign-body reaction through nanotopography: Biocompatibility and immunoisolation properties of a nanofibrous membrane[J]. BIOMATERIALS,2016.
APA	Wang, Kai.,Hou, Wen-Da.,Wang, Xi.,Han, Chengsheng.,Vuletic, Ivan.,...&Luo, Ying.(2016).Overcoming foreign-body reaction through nanotopography: Biocompatibility and immunoisolation properties of a nanofibrous membrane.BIOMATERIALS.
MLA	Wang, Kai,et al."Overcoming foreign-body reaction through nanotopography: Biocompatibility and immunoisolation properties of a nanofibrous membrane".BIOMATERIALS (2016).