Patchouli alcohol attenuates experimental atherosclerosis via inhibiting   macrophage infiltration and its inflammatory responses

doi:10.1016/j.biopha.2016.08.005

CORC > 北京大学 > 工学院

	Patchouli alcohol attenuates experimental atherosclerosis via inhibiting macrophage infiltration and its inflammatory responses
	Wang, Hua-Ting ; Wang, Zun-Zhe ; Wang, Zai-Cun ; Wang, Shu-Mei ; Cai, Xiao-Jun ; Su, Guo-Hai ; Yuan, Zu-Yi
刊名	BIOMEDICINE & PHARMACOTHERAPY
	2016
关键词	Patchouli alcohol Pogostemonis herba Atherosclerosis Macrophage infiltration Macrophage inflammatory responses ANTIINFLAMMATORY DRUGS POGOSTEMONIS HERBA RESVERATROL
DOI	10.1016/j.biopha.2016.08.005
英文摘要	Patchouli alcohol (PA) is a tricyclic sesquiterpene extracted from a traditional Chinese herb pogostemonis herba. Literatures have proven that PA could inhibit inflammatory responses in various inflammatory disease models. However, whether PA could protect against atherosclerosis, a chronic vascular inflammation, is unknown. In this study, we sought to explore this issue in atherosclerosis-prone apolipoprotein E knockout mice fed an atherogenic diet, with or without daily PA intragastrical administration (40 mg/kg). Our results showed that PA administration did not change plasma lipids metabolism, however, it significantly attenuated atherosclerotic plaque burdens in both the aorta and the aortic root. The lesional macrophage content, shown as Mac2 positive areas, was reduced, while the lesional smooth muscle cell and collagen content, shown as a-SMA positive areas and by Sirius red staining, respectively, was not affected in PA-treated mice, compared with non-treated controls. Aortic mRNA expression of macrophage inflammatory cytokines, including MCP-1, iNOS, IL-1b, IL-6, CXCL9 and CXCL11, was also reduced in PA-treated mice. Therefore, we demonstrated that PA could attenuate atherosclerosis, possibly by inhibiting macrophage infiltration and its inflammatory responses. (C) 2016 Elsevier Masson SAS. All rights reserved.; Key Science and Technology Program of Shandong Province [2009GG20002016]; SCI(E); PubMed; ARTICLE; wanghuating65@163.com; zuyiyuanxjtu@163.com; 930-935; 83
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/493224]
专题	工学院
推荐引用方式 GB/T 7714	Wang, Hua-Ting,Wang, Zun-Zhe,Wang, Zai-Cun,et al. Patchouli alcohol attenuates experimental atherosclerosis via inhibiting macrophage infiltration and its inflammatory responses[J]. BIOMEDICINE & PHARMACOTHERAPY,2016.
APA	Wang, Hua-Ting.,Wang, Zun-Zhe.,Wang, Zai-Cun.,Wang, Shu-Mei.,Cai, Xiao-Jun.,...&Yuan, Zu-Yi.(2016).Patchouli alcohol attenuates experimental atherosclerosis via inhibiting macrophage infiltration and its inflammatory responses.BIOMEDICINE & PHARMACOTHERAPY.
MLA	Wang, Hua-Ting,et al."Patchouli alcohol attenuates experimental atherosclerosis via inhibiting macrophage infiltration and its inflammatory responses".BIOMEDICINE & PHARMACOTHERAPY (2016).