Design of magnesium alloys with controllable degradation for biomedical   implants: From bulk to surface

doi:10.1016/j.actbio.2016.09.005

CORC > 北京大学 > 工学院

	Design of magnesium alloys with controllable degradation for biomedical implants: From bulk to surface
	Li, Xia ; Liu, Xiangmei ; Wu, Shuilin ; Yeung, K. W. K. ; Zheng, Yufeng ; Chu, Paul K.
刊名	ACTA BIOMATERIALIA
	2016
关键词	Magnesium alloys Biodegradability Implants Corrosion Surface modification SIMULATED BODY-FLUID IN-VITRO DEGRADATION MICRO-ARC OXIDATION HIGH-PURITY MG ELECTROCHEMICAL CORROSION BEHAVIOR ALPHA-TRICALCIUM PHOSPHATE IMMERSION ION-IMPLANTATION STACKING ORDERED STRUCTURE ZN-ZR ALLOY MECHANICAL ATTRITION TREATMENT
DOI	10.1016/j.actbio.2016.09.005
英文摘要	The combination of high strength, light weight, and natural biodegradability renders magnesium (Mg) based alloys promising in orthopedic implants and cardiovascular stents. Being metallic materials, Mg and Mg alloys made for scaffolds provide the necessary mechanical support for tissue healing and cell growth in the early stage, while natural degradation and reabsorption by surrounding tissues in the later stage make an unnecessarily follow-up removal surgery. However, uncontrolled degradation may collapse the scaffolds resulting in premature implant failure, and there has been much research in controlling the degradation rates of Mg alloys. This paper reviews recent progress in the design of novel Mg alloys, surface modification and corrosion mechanisms under different conditions, and describes the effects of the structure, composition, and surface conditions on the degradation behavior in vitro and in vivo. Statement of Significance Owing to their unique mechanical properties, biodegradability, biocompatibility, Mg based biomaterials are becoming the most promising substitutes for tissue regeneration for impaired bone, vascular and other tissues because these scaffolds can provide not only ideal space for the growth and differentiation of seeded cells but also enough strength before the formation of normal tissues. The most important is that these scaffolds can be fully degraded after tissue regeneration, which can satisfy the increasing demand for better biomedical devices and functional tissue engineering biomaterials in the world. However, the rapid degradation rate of these scaffolds restricts the wide application in clinic. This paper reviews recent progress on how to control the degrdation rate based on the relevant corrosion mechanisms through the design of porous structure, phase structure, grains, and amorphous structure as well as surface modification, which will be beneficial to the better understanding and functional design of Mg -based scaffolds for wide clinical applications in tissue reconstruction in near futures. (C) 2016 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.; Special Prophase Program for Key Basic Research of the Ministry of Science and Technology of China (973 Program) [2014CB660809]; National Natural Science Foundation of China [51422102, 81271715]; Hong Kong Research Grants Council (RGC) General Research Funds (GRF) [11301215]; Hubei Provincial Natural Science Foundation [2013CFA018, 2014CFB551]; SCI(E); PubMed; REVIEW; liuxiangmei1978@163.com; shuilin.wu@hubu.edu.cn; paul.chu@cityu.edu.hk; 2-30; 45
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/492945]
专题	工学院
推荐引用方式 GB/T 7714	Li, Xia,Liu, Xiangmei,Wu, Shuilin,et al. Design of magnesium alloys with controllable degradation for biomedical implants: From bulk to surface[J]. ACTA BIOMATERIALIA,2016.
APA	Li, Xia,Liu, Xiangmei,Wu, Shuilin,Yeung, K. W. K.,Zheng, Yufeng,&Chu, Paul K..(2016).Design of magnesium alloys with controllable degradation for biomedical implants: From bulk to surface.ACTA BIOMATERIALIA.
MLA	Li, Xia,et al."Design of magnesium alloys with controllable degradation for biomedical implants: From bulk to surface".ACTA BIOMATERIALIA (2016).