Biocompatibility Assessment of Detonation Nanodiamond in Non-Human   Primates and Rats Using Histological, Hematologic, and Urine Analysis

doi:10.1021/acsnano.6b00839

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	Biocompatibility Assessment of Detonation Nanodiamond in Non-Human Primates and Rats Using Histological, Hematologic, and Urine Analysis
	Moore, Laura ; Yang, Junyu ; Lang, Thanh T. Ha ; Osawa, Eiji ; Lee, Don-Kenn ; Johnson, William D. ; Xi, Jianzhong ; Chow, Edward Kai-Hua ; Ho, Dean
刊名	ACS NANO
	2016
关键词	nanodiamond biocompatibility nanomedicine biomaterial carbon FLUORESCENT NANODIAMONDS CLINICAL-CHEMISTRY REFERENCE VALUES RHESUS-MONKEYS BREAST-CANCER STEM-CELLS IN-VIVO DELIVERY CYNOMOLGUS HYDROGELS
DOI	10.1021/acsnano.6b00839
英文摘要	Detonation nanodiamonds (DNDs) have been widely explored for biomedical applications ranging from cancer therapy to magnetic resonance imaging due to several promising properties. These include faceted surfaces that mediate potent drug binding and water coordination that have resulted in marked enhancements to the efficacy and safety of drug delivery and imaging. In addition, scalable processing of DNDs yields uniform particles. Furthermore, a broad spectrum of biocompatibility studies has shown that DNDs appear to be well-tolerated. Prior to the clinical translation of DNDs for indications that are addressed via intravenous administration, comprehensive assessment of DND safety in both small and large animal preclinical models is needed. This article reports the results of a DND biocompatibility study in both non-human primates and rats. The rat study was performed as a multiple dose subacute investigation in two cohorts that lasted for 2 weeks and included histological, serum, and urine analysis. The non-human primate study was performed as a dual gender, multiple dose, and long-term investigation in both standard/clinically relevant and elevated dosing cohorts that lasted for 6 months and included comprehensive serum, urine, histological, and body weight analysis. The results from these studies indicate that NDs are well-tolerated at clinically relevant doses. Examination of dose-dependent changes in biomarker levels provides important guidance for the downstream in-human validation of DNDs for clinical drug delivery and imaging.; National Cancer Institute [1F30CA174156-01, U54CA151880]; College of Engineering, Peking University; NSFC [81325010, 81421004, 31371443]; National Research Foundation Cancer Science Institute of Singapore RCE Main Grant; National Medical Research Council [NMRC CBRGNIG NMRC/BNIG/2012/2013]; Ministry of Education Academic Research Fund (MOE AcRF) [T1-2012 Oct-11]; Ministry of Education Academic Research Fund (Seed Fund Grant) [T1-BSRG 2014-05]; NCIS Yong Siew Yoon Research Grant; National Science Foundation CAREER Award [CMMI-1350197]; Center for Scalable and Integrated NanoManufacturing [DMI-0327077]; V Foundation for Cancer Research Scholars Award; Wallace H. Coulter Foundation Translational Research Award; Society for Laboratory Automation and Screening Endowed Fellowship; Beckman Coulter Life Sciences; American Academy of Implant Dentistry Research Foundation [20150460]; Departments of Biomedical Engineering and Mechanical Engineering at Northwestern University; [CMMI-0856492]; [DMR-1343991]; [OISE-1444100]; SCI(E); EI; PubMed; ARTICLE; xi@coe.pku.edu.cn; csikce@nus.edu.sg; dean.ho@ucla.edu; 8; 7385-7400; 10
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/491720]
专题	工学院
推荐引用方式 GB/T 7714	Moore, Laura,Yang, Junyu,Lang, Thanh T. Ha,et al. Biocompatibility Assessment of Detonation Nanodiamond in Non-Human Primates and Rats Using Histological, Hematologic, and Urine Analysis[J]. ACS NANO,2016.
APA	Moore, Laura.,Yang, Junyu.,Lang, Thanh T. Ha.,Osawa, Eiji.,Lee, Don-Kenn.,...&Ho, Dean.(2016).Biocompatibility Assessment of Detonation Nanodiamond in Non-Human Primates and Rats Using Histological, Hematologic, and Urine Analysis.ACS NANO.
MLA	Moore, Laura,et al."Biocompatibility Assessment of Detonation Nanodiamond in Non-Human Primates and Rats Using Histological, Hematologic, and Urine Analysis".ACS NANO (2016).