Overexpression of LAMC2 predicts poor prognosis in colorectal cancer   patients and promotes cancer cell proliferation, migration, and invasion

doi:10.1177/1010428317705849

CORC > 北京大学 > 工学院

	Overexpression of LAMC2 predicts poor prognosis in colorectal cancer patients and promotes cancer cell proliferation, migration, and invasion
	Huang, Dandan ; Du, Changzheng ; Ji, Dengbo ; Xi, Jianzhong ; Gu, Jin
刊名	TUMOR BIOLOGY
	2017
关键词	Colorectal cancer laminin gamma 2 prognosis diagnosis biomarker LAMININ GAMMA-2 CHAIN EXPRESSION CARCINOMA ADENOCARCINOMA PROGRESSION GENES
DOI	10.1177/1010428317705849
英文摘要	Laminin gamma 2 (LAMC2) has been reported to be involved in the development and progression of a variety of tumors. However, its function in human colorectal cancer is unclear. Our study aimed to investigate the role of laminin gamma 2 in colorectal cancer. We first performed the multiple Kaplan-Meier survival analysis of laminin gamma 2 in a cohort of Gene Expression Omnibus datasets and evaluated its relationship with clinical outcomes of colorectal cancer patients. Then, we established stable colorectal cancer cell lines with laminin gamma 2 overexpression and examined the functional assays in vitro. Finally the expression pattern of laminin gamma 2 in colorectal cancer clinical samples was analyzed by immunohistochemistry and quantitative real-time polymerase chain reaction. We found that laminin gamma 2 was significantly correlated with poor clinical outcomes such as disease-specific, recurrence-free, disease-free, and overall survival in colorectal cancer. Moreover, stably overexpressing laminin gamma 2 promoted proliferation, migration, and invasion of colorectal cancer cells. In addition, overexpressed laminin gamma 2 was identified in tumor tissues compared with paired adjacent normal tissues and was related to tumor-node-metastasis stage (p = 0.001) and lymph node metastasis (p < 0.001). In summary, our results strongly suggest that laminin gamma 2 may be a potential prognostic biomarker and therapeutic target in colorectal cancer.; National Natural Science Foundation [81201965]; SCI(E); ARTICLE; 6; 39
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/472638]
专题	工学院
推荐引用方式 GB/T 7714	Huang, Dandan,Du, Changzheng,Ji, Dengbo,et al. Overexpression of LAMC2 predicts poor prognosis in colorectal cancer patients and promotes cancer cell proliferation, migration, and invasion[J]. TUMOR BIOLOGY,2017.
APA	Huang, Dandan,Du, Changzheng,Ji, Dengbo,Xi, Jianzhong,&Gu, Jin.(2017).Overexpression of LAMC2 predicts poor prognosis in colorectal cancer patients and promotes cancer cell proliferation, migration, and invasion.TUMOR BIOLOGY.
MLA	Huang, Dandan,et al."Overexpression of LAMC2 predicts poor prognosis in colorectal cancer patients and promotes cancer cell proliferation, migration, and invasion".TUMOR BIOLOGY (2017).