CuInS2/ZnS Quantum Dots Conjugating Gd(III) Chelates for Near-Infrared   Fluorescence and Magnetic Resonance Bimodal Imaging

doi:10.1021/acsami.7b05867

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	CuInS2/ZnS Quantum Dots Conjugating Gd(III) Chelates for Near-Infrared Fluorescence and Magnetic Resonance Bimodal Imaging
	Yang, Yongbo ; Lin, Li ; Jing, Lijia ; Yue, Xiuli ; Dai, Zhifei
刊名	ACS APPLIED MATERIALS & INTERFACES
	2017
关键词	magnetic resonance imaging near-Infrared fluorescence imaging bimodal contrast agent quantum dots Gd(III) chelate GOLD NANOPARTICLES DRUG-DELIVERY SYNERGISTIC THERAPY MN-PORPHYRIN NANOCRYSTALS DOXORUBICIN CANCER BIODISTRIBUTION RELAXIVITY NANOPROBE
DOI	10.1021/acsami.7b05867
英文摘要	A bimodal contrast nanoagent was developed by chelating gadolinium ions to 2-[bis[2-[carboxymethyl-[2-oxo-2-(2-s ulfanylethyl-amino)ethyl] amino] ethyl] amino] acetic acid (DTDTPA)-modified CuInS2/ZnS quantum dots (QDs). The longitudinal relaxivity (r(1)) of the resulted QDs@DTDTPA-Gd nanoparticles (NPs) was calculated to be 9.91 mM(-1) s(-1), which was 2.5 times as high as that of clinically approved Gd-DTPA (3.9 mM(-1) s(-1)). In addition, the in vivo imaging experiments showed that QDs@DTDTPA-Gd NPs could enhance both near-infrared fluorescence and T-1-weighted magnetic resonance (MR) imaging of tumor tissue through passive targeting accumulation. Moreover, the high colloidal and fluorescence stabilities and good biocompatibility indicate that QDs@DTDTPA-Gd NPs have a great potential for use as an efficient nanoagent to integrate the extremely high sensitivity of fluorescence imaging to the high resolution of MR imaging. Integration of bimodal detectability in the same agent of QDs@DTDTPA-Gd NPs can avoid extra stress on the blood clearance mechanisms as the administration of multiple dose of agents.; National Key Research and Development Program of China [2016YFA0201400]; National Natural Science Foundation of China [81371580]; State Key Program of the National Natural Science Foundation of China [81230036]; Foundation for Innovative Research Groups of the National Natural Science Foundation of China [81421004]; SCI(E); ARTICLE; 28; 23450-23457; 9
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/472073]
专题	工学院
推荐引用方式 GB/T 7714	Yang, Yongbo,Lin, Li,Jing, Lijia,et al. CuInS2/ZnS Quantum Dots Conjugating Gd(III) Chelates for Near-Infrared Fluorescence and Magnetic Resonance Bimodal Imaging[J]. ACS APPLIED MATERIALS & INTERFACES,2017.
APA	Yang, Yongbo,Lin, Li,Jing, Lijia,Yue, Xiuli,&Dai, Zhifei.(2017).CuInS2/ZnS Quantum Dots Conjugating Gd(III) Chelates for Near-Infrared Fluorescence and Magnetic Resonance Bimodal Imaging.ACS APPLIED MATERIALS & INTERFACES.
MLA	Yang, Yongbo,et al."CuInS2/ZnS Quantum Dots Conjugating Gd(III) Chelates for Near-Infrared Fluorescence and Magnetic Resonance Bimodal Imaging".ACS APPLIED MATERIALS & INTERFACES (2017).