Disrupted Default Mode Network and Basal Craving in Male   Heroin-Dependent Individuals: A Resting-State fMRI Study

doi:10.4088/JCP.15m09965

CORC > 北京大学 > 工学院

	Disrupted Default Mode Network and Basal Craving in Male Heroin-Dependent Individuals: A Resting-State fMRI Study
	Li, Qiang ; Li, Zhe ; Li, Wei ; Zhang, Yi ; Wang, Yarong ; Zhu, Jia ; Chen, Jiajie ; Li, Yongbin ; Yan, Xuejiao ; Ye, Jianjun ; Li, Linbin ; Wang, Wei ; Liu, Yijun
刊名	JOURNAL OF CLINICAL PSYCHIATRY
	2016
关键词	MEDIAL PREFRONTAL CORTEX COCAINE ADDICTION DRUG-ADDICTION BRAIN ACTIVITY SMOKING CUES FUNCTIONAL CONNECTIVITY COGNITIVE IMPAIRMENT BASOLATERAL AMYGDALA SUBSEQUENT RELAPSE MAJOR DEPRESSION
DOI	10.4088/JCP.15m09965
英文摘要	Background: Craving is associated with a high probability of relapse. However, the relationship between functional connectivity in the default mode network (DMN) during resting state and basal craving of heroin-dependent individuals remains unknown. Methods: Data used in the present study were collected between August 10, 2009, and June 28, 2011. Twenty-four male heroin-dependent individuals based on DSM-IV criteria and 20 male healthy control subjects participated in a study of resting-state functional magnetic resonance imaging. The basal heroin craving of the heroin-dependent group was evaluated. The DMN networks were identified by group independent component analysis. The between-group difference in functional connectivity was analyzed, and the relationship between functional connectivity in the DMN and basal heroin craving in the heroin-dependent group was also analyzed. Results: In all subjects, 2 spatially independent default mode subnetworks were identified: the anterior and posterior subnetworks. The anterior subnetwork, mainly the dorsal medial prefrontal cortex, showed decreased functional connectivity in the heroin-dependent group relative to the healthy control group (P < .05, familywise error corrected). However, the functional connectivity in dorsal medial prefrontal cortex was negatively correlated with the basal craving of the heroin group (P = .01, r = -0.50). No significant difference in the functional connectivity of the posterior subnetwork was found. Conclusions: Our findings suggest that abnormal functional connectivity within the anterior subnetwork of DMN in heroin-dependent individuals is associated with basal heroin craving, and it may serve as neural underpinnings for the mechanism of heroin addiction. (C) Copyright 2016 Physicians Postgraduate Press, Inc.; National Natural Science Foundation of China [81201081, 81371532, 81471648, 81401393, 81071142, 81071143, 81470816, 81271549, 61131003]; Technology Innovation Development Foundation of Tangdu Hospital [2013LCYJ003]; SCI(E); SSCI; ARTICLE; tdwangw@126.com; 10; E1211-+; 77
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/458751]
专题	工学院
推荐引用方式 GB/T 7714	Li, Qiang,Li, Zhe,Li, Wei,et al. Disrupted Default Mode Network and Basal Craving in Male Heroin-Dependent Individuals: A Resting-State fMRI Study[J]. JOURNAL OF CLINICAL PSYCHIATRY,2016.
APA	Li, Qiang.,Li, Zhe.,Li, Wei.,Zhang, Yi.,Wang, Yarong.,...&Liu, Yijun.(2016).Disrupted Default Mode Network and Basal Craving in Male Heroin-Dependent Individuals: A Resting-State fMRI Study.JOURNAL OF CLINICAL PSYCHIATRY.
MLA	Li, Qiang,et al."Disrupted Default Mode Network and Basal Craving in Male Heroin-Dependent Individuals: A Resting-State fMRI Study".JOURNAL OF CLINICAL PSYCHIATRY (2016).