The C-Terminal Arm of the Human Papillomavirus Major Capsid Protein Is   Immunogenic and Involved in Virus-Host Interaction

doi:10.1016/j.str.2016.04.008

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	The C-Terminal Arm of the Human Papillomavirus Major Capsid Protein Is Immunogenic and Involved in Virus-Host Interaction
	Li, Zhihai ; Yan, Xiaodong ; Yu, Hai ; Wang, Daning ; Song, Shuo ; Li, Yunbing ; He, Maozhou ; Hong, Qiyang ; Zheng, Qingbing ; Zhao, Qinjian ; Gu, Ying ; Zhang, Jun ; Janssen, Mandy E. W. ; Cardone, Giovanni ; Olson, Norman H. ; Baker, Timothy S. ; Li, Shaowei ; Xia, Ningshao
刊名	STRUCTURE
	2016
关键词	MOLECULAR-DYNAMICS CRYOELECTRON MICROSCOPY BOVINE PAPILLOMAVIRUS MONOCLONAL-ANTIBODIES IMAGE-RECONSTRUCTION ELECTRON-MICROSCOPY HEPARAN-SULFATE CERVICAL-CANCER DNA-BINDING PARTICLES
DOI	10.1016/j.str.2016.04.008
英文摘要	Cervical cancer is the second most prevalent malignant tumor among women worldwide. High-risk human papillomaviruses (HPVs) are believed to be the major causative pathogens of mucosal epithelial cancers including cervical cancer. The HPV capsid is made up of 360 copies of major (L1) and 72 copies of minor (L2) capsid proteins. To date, limited high-resolution structural information about the HPV capsid has hindered attempts to understand details concerning the mechanisms by which HPV assembles and infects cells. In this study, we have constructed a pseudo-atomic model of the HPV59 L1-only capsid and demonstrate that the C-terminal armof L1 participates in virus-host interactions. Moreover, when conjugated to a scaffold protein, keyhole limpet hemocyanin (KLH), this arm is immunogenic in vivo. These results provide new insights that will help elucidate HPV biology, and hence pave a way for the design of next-generation HPV vaccines.; Chinese government: National Natural Science Foundation [81172885, 81471934, 81371818, 81401669]; National Key Projects in Science and Technology [2012ZX09101316, 2014AA021302]; Fujian Provincial Science Fund [2013J05053]; NIH [R37-GM33050]; University of California San Diego; Agouron Foundation; SCI(E); PubMed; ARTICLE; tsb@ucsd.edu; shaowei@xmu.edu.cn; 6; 874-885; 24
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/433416]
专题	工学院
推荐引用方式 GB/T 7714	Li, Zhihai,Yan, Xiaodong,Yu, Hai,et al. The C-Terminal Arm of the Human Papillomavirus Major Capsid Protein Is Immunogenic and Involved in Virus-Host Interaction[J]. STRUCTURE,2016.
APA	Li, Zhihai.,Yan, Xiaodong.,Yu, Hai.,Wang, Daning.,Song, Shuo.,...&Xia, Ningshao.(2016).The C-Terminal Arm of the Human Papillomavirus Major Capsid Protein Is Immunogenic and Involved in Virus-Host Interaction.STRUCTURE.
MLA	Li, Zhihai,et al."The C-Terminal Arm of the Human Papillomavirus Major Capsid Protein Is Immunogenic and Involved in Virus-Host Interaction".STRUCTURE (2016).