Bioinspired anchoring AgNPs onto micro-nanoporous TiO2 orthopedic   coatings: Trap-killing of bacteria, surface-regulated osteoblast   functions and host responses

doi:10.1016/j.biomaterials.2015.10.035

CORC > 北京大学 > 工学院

	Bioinspired anchoring AgNPs onto micro-nanoporous TiO2 orthopedic coatings: Trap-killing of bacteria, surface-regulated osteoblast functions and host responses
	Jia, Zhaojun ; Xiu, Peng ; Li, Ming ; Xu, Xuchen ; Shi, Yuying ; Cheng, Yan ; Wei, Shicheng ; Zheng, Yufeng ; Xi, Tingfei ; Cai, Hong ; Liu, Zhongjun
刊名	BIOMATERIALS
	2016
关键词	TiO2/Ag coatings Micro-nano/porous Poly(dopamine) Antibacterial coatings Silver nanoparticles (AgNPs) SILVER NANOPARTICLES ANTIBACTERIAL COATINGS TITANIA NANOTUBES ADHESION POLYDOPAMINE FUNCTIONALIZATION CYTOTOXICITY CELLS IMPLANTS BIOCOMPATIBILITY
DOI	10.1016/j.biomaterials.2015.10.035
英文摘要	The therapeutic applications of silver nanoparticles (AgNPs) against biomedical device-associated infections (BAI), by local delivery, are encountered with risks of detachment, instability and nanotoxicity in physiological milieus. To firmly anchor AgNPs onto modified biomaterial surfaces through tight physicochemical interactions would potentially relieve these concerns. Herein, we present a strategy for hierarchical TiO2/Ag coating, in an attempt to endow medical titanium (Ti) with anticorrosion and antibacterial properties whilst maintaining normal biological functions. In brief, by harnessing the adhesion and reactivity of bioinspired polydopamine, silver nanoparticles were easily immobilized onto peripheral surface and incorporated into interior cavity of a micro/nanoporous TiO2 ceramic coating in situ grown from template Ti. The resulting coating protected the substrate well from corrosion and gave a sustained release of Ag+ up to 28 d. An interesting germicidal effect, termed "trap-killing", was observed against Staphylococcus aureus strain. The multiple osteoblast responses, i.e. adherence, spreading, proliferation, and differentiation, were retained normal or promoted, via a putative surface-initiated self-regulation mechanism. After subcutaneous implantation for a month, the coated specimens elicited minimal, comparable inflammatory responses relative to the control. Moreover, this simple and safe functionalization strategy manifested a good degree of flexibility towards three-dimensional sophisticated objects. Expectedly, it can become a prospective bench to bedside solution to current challenges facing orthopedics. (C) 2015 Elsevier Ltd. All rights reserved.; Project of Scientific and Technical Plan of Beijing [Z141100002814008]; National Natural Science Foundation of China [31370954]; State Key Laboratory of Bioelectronics Open Research Fund of China (Chien-Shiung Wu Laboratory); National Basic Research Program (973) of China [2012CB619102]; SCI(E); EI; PubMed; ARTICLE; chengyan@pku.edu.cn; 203-222; 75
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/417178]
专题	工学院
推荐引用方式 GB/T 7714	Jia, Zhaojun,Xiu, Peng,Li, Ming,et al. Bioinspired anchoring AgNPs onto micro-nanoporous TiO2 orthopedic coatings: Trap-killing of bacteria, surface-regulated osteoblast functions and host responses[J]. BIOMATERIALS,2016.
APA	Jia, Zhaojun.,Xiu, Peng.,Li, Ming.,Xu, Xuchen.,Shi, Yuying.,...&Liu, Zhongjun.(2016).Bioinspired anchoring AgNPs onto micro-nanoporous TiO2 orthopedic coatings: Trap-killing of bacteria, surface-regulated osteoblast functions and host responses.BIOMATERIALS.
MLA	Jia, Zhaojun,et al."Bioinspired anchoring AgNPs onto micro-nanoporous TiO2 orthopedic coatings: Trap-killing of bacteria, surface-regulated osteoblast functions and host responses".BIOMATERIALS (2016).