Engineering the heart: Evaluation of conductive nanomaterials for   improving implant integration and cardiac function

doi:10.1038/srep03733

CORC > 北京大学 > 工学院

	Engineering the heart: Evaluation of conductive nanomaterials for improving implant integration and cardiac function
	Zhou, Jin ; Chen, Jun ; Sun, Hongyu ; Qiu, Xiaozhong ; Mou, Yongchao ; Liu, Zhiqiang ; Zhao, Yuwei ; Li, Xia ; Han, Yao ; Duan, Cuimi ; Tang, Rongyu ; Wang, Chunlan ; Zhong, Wen ; Liu, Jie ; Luo, Ying ; Xing, Malcolm ; Wang, Changyong
刊名	scientific reports
	2014
关键词	WALLED CARBON NANOTUBES INTEGRIN-LINKED KINASE SHEET MANIPULATION TECHNIQUE MYOCARDIAL-INFARCTION MODEL MESENCHYMAL STEM-CELLS RAT HEARTS ISCHEMIC-MYOCARDIUM IN-VITRO TISSUE REPAIR
DOI	10.1038/srep03733
英文摘要	Recently, carbon nanotubes together with other types of conductive materials have been used to enhance the viability and function of cardiomyocytes in vitro. Here we demonstrated a paradigm to construct ECTs for cardiac repair using conductive nanomaterials. Single walled carbon nanotubes (SWNTs) were incorporated into gelatin hydrogel scaffolds to construct three-dimensional ECTs. We found that SWNTs could provide cellular microenvironment in vitro favorable for cardiac contraction and the expression of electrochemical associated proteins. Upon implantation into the infarct hearts in rats, ECTs structurally integrated with the host myocardium, with different types of cells observed to mutually invade into implants and host tissues. The functional measurements showed that SWNTs were essential to improve the performance of ECTs in inhibiting pathological deterioration of myocardium. This work suggested that conductive nanomaterials hold therapeutic potential in engineering cardiac tissues to repair myocardial infarction.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000329848100023&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Multidisciplinary Sciences; SCI(E); PubMed; 13; ARTICLE; xing@cc.umanitoba.ca; wangchy@bmi.ac.cn; 3733; 4
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/342757]
专题	工学院
推荐引用方式 GB/T 7714	Zhou, Jin,Chen, Jun,Sun, Hongyu,et al. Engineering the heart: Evaluation of conductive nanomaterials for improving implant integration and cardiac function[J]. scientific reports,2014.
APA	Zhou, Jin.,Chen, Jun.,Sun, Hongyu.,Qiu, Xiaozhong.,Mou, Yongchao.,...&Wang, Changyong.(2014).Engineering the heart: Evaluation of conductive nanomaterials for improving implant integration and cardiac function.scientific reports.
MLA	Zhou, Jin,et al."Engineering the heart: Evaluation of conductive nanomaterials for improving implant integration and cardiac function".scientific reports (2014).