Association of the g.19074G &gt; A genetic variant in the osteoprotegerin   gene with bone mineral density in Chinese postmenopausal women

doi:10.4238/2014.August.28.9

CORC > 北京大学 > 工学院

	Association of the g.19074G > A genetic variant in the osteoprotegerin gene with bone mineral density in Chinese postmenopausal women
	Zhang, Y. D. ; Zhang, Z. ; Zhou, N. F. ; Jia, W. T. ; Cheng, X. G. ; Wei, X. J.
刊名	genetics and molecular research
	2014
关键词	Bone mineral density Genetic variant Osteoprotegerin gene Primary osteoporosis Risk factor VITAMIN-D-RECEPTOR OSTEOPOROTIC FRACTURES LYS3ASN POLYMORPHISM COMMERCIAL CATTLE PROMOTER RISK OPG EPIDEMIOLOGY DIAGNOSIS MASS
DOI	10.4238/2014.August.28.9
英文摘要	Primary osteoporosis is a common health problem in postmenopausal women. This study aimed to detect the association of the g.19074G>A genetic variant in the osteoprotegerin gene (OPG) with bone mineral density (BMD) and primary osteoporosis. The created restriction site-polymerase chain reaction method was used to investigate the g.19074G>A genetic variant. The BMD of the femoral neck hip, lumbar spine (L2-4), and total hip were assessed by dual-energy X-ray absorptiometry (DEXA) in 856 unrelated Chinese postmenopausal women. We found significant differences in the BMDs of the femoral neck hip, lumbar spine (L2-4), and total hip among different genotypes; individuals with the GG genotype had significantly higher BMDs than those with the GA and AA genotypes (P < 0.05). Our results indicated that the A allele was an increased risk factor for primary osteoporosis and the g.19074G>A genetic variant of the OPG gene was associated with BMD and primary osteoporosis in Chinese postmenopausal women.; Biochemistry & Molecular Biology; Genetics & Heredity; SCI(E); PubMed; 0; ARTICLE; yadongzhang_12@sina.com; 3; 6646-6652; 13
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/342256]
专题	工学院
推荐引用方式 GB/T 7714	Zhang, Y. D.,Zhang, Z.,Zhou, N. F.,et al. Association of the g.19074G > A genetic variant in the osteoprotegerin gene with bone mineral density in Chinese postmenopausal women[J]. genetics and molecular research,2014.
APA	Zhang, Y. D.,Zhang, Z.,Zhou, N. F.,Jia, W. T.,Cheng, X. G.,&Wei, X. J..(2014).Association of the g.19074G > A genetic variant in the osteoprotegerin gene with bone mineral density in Chinese postmenopausal women.genetics and molecular research.
MLA	Zhang, Y. D.,et al."Association of the g.19074G > A genetic variant in the osteoprotegerin gene with bone mineral density in Chinese postmenopausal women".genetics and molecular research (2014).