Interstitial diffuse radiance spectroscopy of gold nanocages and   nanorods in bulk muscle tissues

doi:10.2147/IJN.S79246

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	Interstitial diffuse radiance spectroscopy of gold nanocages and nanorods in bulk muscle tissues
	Grabtchak, Serge ; Montgomery, Logan G. ; Pang, Bo ; Wang, Yi ; Zhang, Chao ; Li, Zhiyuan ; Xia, Younan ; Whelan, William M.
刊名	international journal of nanomedicine
	2015
关键词	gold nanocages gold nanorods turbid media porcine muscles diffuse radiance spectroscopy Beer-Lambert law perturbation NEAR-INFRARED SPECTROSCOPY BEER-LAMBERT LAW PHOTON MIGRATION TURBID MEDIA NANOPARTICLES SCATTERING PHANTOMS CANCER MODEL
DOI	10.2147/IJN.S79246
英文摘要	Radiance spectroscopy was applied to the interstitial detection of localized inclusions containing Au nanocages or nanorods with various concentrations embedded in porcine muscle phantoms. The radiance was quantified using a perturbation approach, which enabled the separation of contributions from the porcine phantom and the localized inclusion, with the inclusion serving as a perturbation probe of photon distributions in the turbid medium. Positioning the inclusion at various places in the phantom allowed for tracking of photons that originated from a light source, passed through the inclusion's location, and reached a detector. The inclusions with high extinction coefficients were able to absorb nearly all photons in the range of 650-900 nm, leading to a spectrally flat radiance signal. This signal could be converted to the relative density of photons incident on the inclusion. Finally, the experimentally measured quantities were expressed via the relative perturbation and arranged into the classical Beer-Lambert law that allowed one to extract the extinction coefficients of various types of Au nanoparticles in both the transmission and back reflection geometries. It was shown that the spatial variation of perturbation could be described as 1/r dependence, where r is the distance between the inclusion and the detector. Due to a larger absorption cross section, Au nanocages produced greater perturbations than Au nanorods of equal particle concentration, indicating a better suitability of Au nanocages as contrast agents for optical measurements in turbid media. Individual measurements from different inclusions were combined into detectability maps.; Nanoscience & Nanotechnology; Pharmacology & Pharmacy; SCI(E); PubMed; 0; ARTICLE; sgrabtchak@upei.ca; 1307-1320; 10
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/341440]
专题	工学院
推荐引用方式 GB/T 7714	Grabtchak, Serge,Montgomery, Logan G.,Pang, Bo,et al. Interstitial diffuse radiance spectroscopy of gold nanocages and nanorods in bulk muscle tissues[J]. international journal of nanomedicine,2015.
APA	Grabtchak, Serge.,Montgomery, Logan G..,Pang, Bo.,Wang, Yi.,Zhang, Chao.,...&Whelan, William M..(2015).Interstitial diffuse radiance spectroscopy of gold nanocages and nanorods in bulk muscle tissues.international journal of nanomedicine.
MLA	Grabtchak, Serge,et al."Interstitial diffuse radiance spectroscopy of gold nanocages and nanorods in bulk muscle tissues".international journal of nanomedicine (2015).