Hemodynamic Effects of Furosemide on Renal Perfusion as Evaluated by   ASL-MRI

doi:10.1016/j.acra.2012.04.021

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	Hemodynamic Effects of Furosemide on Renal Perfusion as Evaluated by ASL-MRI
	Wang, Jing ; Zhang, Yudong ; Yang, Xuedong ; Wang, Xiaoying ; Zhang, Jue ; Fang, Jing ; Jiang, Xuexiang
刊名	academic radiology
	2012
关键词	Arterial spin labeling furosemide renal blood flow autoregulation BLOOD-FLOW AUTOREGULATION CEREBRAL PERFUSION LOOP DIURETICS MECHANISMS FILTRATION RATS VASODILATION RELAXATION MEDULLARY EXCRETION
DOI	10.1016/j.acra.2012.04.021
英文摘要	Rationale and Objectives: The aim of this study was to investigate the short-term effects of furosemide on renal perfusion by using arterial spin labeling (ASL) magnetic resonance imaging. Materials and Methods: Eleven healthy human subjects were enrolled in the study. The measurement of renal blood flow (RBF) was performed by applying an ASL technique with flow-sensitive alternating inversion recovery spin preparation and a single-shot fast spin-echo imaging strategy on a 3.0-T magnetic resonance scanner. For all subjects, the ASL magnetic resonance images were obtained before agent injection as a baseline scan. Then 20 mg of furosemide was injected intravenously. Postfurosemide ASL images were acquired following administration to evaluate the renal hemodynamic response. Results: Postinjection scans showed that cortical RBF decreased from 366.59 +/- 41.19 mL/100 g/min at baseline to 314.33 +/- 48.83 mL/100 g/min at 10 minutes after the administration of furosemide (paired t test, P = .04 vs baseline), and medullary RBF decreased from 118.59 +/- 24.69 mL/100 g/min at baseline to 97.38 +/- 18.40 mL/100 g/min at 10 minutes after the administration of furosemide (paired t test, P = .01 vs baseline). There was a negative correlation between the furosemide-induced diuretic effect and the reduction of RBF (Spearman's r = -0.61). Conclusions: The dominant hemodynamic effect of furosemide on the kidney is associated with a decrease in both cortical and medullary blood perfusion. Furthermore, the quantitative ASL technique may provide an alternative way to noninvasively monitor the change in renal function due to furosemide administration.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000309193700005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Radiology, Nuclear Medicine & Medical Imaging; SCI(E); PubMed; 5; ARTICLE; 10; 1194-1200; 19
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/327099]
专题	工学院
推荐引用方式 GB/T 7714	Wang, Jing,Zhang, Yudong,Yang, Xuedong,et al. Hemodynamic Effects of Furosemide on Renal Perfusion as Evaluated by ASL-MRI[J]. academic radiology,2012.
APA	Wang, Jing.,Zhang, Yudong.,Yang, Xuedong.,Wang, Xiaoying.,Zhang, Jue.,...&Jiang, Xuexiang.(2012).Hemodynamic Effects of Furosemide on Renal Perfusion as Evaluated by ASL-MRI.academic radiology.
MLA	Wang, Jing,et al."Hemodynamic Effects of Furosemide on Renal Perfusion as Evaluated by ASL-MRI".academic radiology (2012).