CRAFT: Multimodality confocal skin imaging for early cancer diagnosis

doi:10.1002/jbio.201100124

CORC > 北京大学 > 工学院

	CRAFT: Multimodality confocal skin imaging for early cancer diagnosis
	Peng, Tong ; Xie, Hao ; Ding, Yichen ; Wang, Weichao ; Li, Zhiming ; Jin, Dayong ; Tang, Yuanhe ; Ren, Qiushi ; Xi, Peng
刊名	journal of biophotonics
	2012
关键词	multimodality autofluorescence reflectance cancer melanoma RESOLVED FLUORESCENCE SPECTROSCOPY BASAL-CELL CARCINOMA IN-VIVO CERVICAL-TISSUE MICROSCOPY REFLECTANCE TOMOGRAPHY SCATTERING DYSPLASIA NAD(P)H
DOI	10.1002/jbio.201100124
英文摘要	Although histological analysis serves as a gold standard to cancer diagnosis, its application on skin cancer detection is largely prohibited due to its invasive nature. To obtain both the structural and pathological information in situ, a Confocal Reflectance/Auto-Fluorescence Tomography (CRAFT) system was established to examine the skin sites in vivo with both reflectance and autofluorescence modes simultaneously. Nude mice skin with cancerous sites and normal skin sites were imaged and compared with the system. The cellular density and reflective intensity in cancerous sites reflects the structural change of the tissue. With the decay coefficient analysis, the corresponding NAD(P)H decay index for cancerous sites is 1.65-fold that of normal sites, leading to a 97.8% of sensitivity and specificity for early cancer diagnosis. The results are verified by the followed histological analysis. Therefore, CRAFT may provide a novel method for the in vivo, non-invasive diagnosis of early cancer. (C) 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim); Biochemical Research Methods; Biophysics; Optics; SCI(E); EI; PubMed; 2; ARTICLE; 5-6,SI; 469-476; 5
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/315671]
专题	工学院
推荐引用方式 GB/T 7714	Peng, Tong,Xie, Hao,Ding, Yichen,et al. CRAFT: Multimodality confocal skin imaging for early cancer diagnosis[J]. journal of biophotonics,2012.
APA	Peng, Tong.,Xie, Hao.,Ding, Yichen.,Wang, Weichao.,Li, Zhiming.,...&Xi, Peng.(2012).CRAFT: Multimodality confocal skin imaging for early cancer diagnosis.journal of biophotonics.
MLA	Peng, Tong,et al."CRAFT: Multimodality confocal skin imaging for early cancer diagnosis".journal of biophotonics (2012).