Altered baseline brain activities before food intake in obese men: A   resting state fMRI study

doi:10.1016/j.neulet.2014.10.020

CORC > 北京大学 > 工学院

	Altered baseline brain activities before food intake in obese men: A resting state fMRI study
	Zhang, Bin ; Tian, Derun ; Yu, Chunshui ; Zhang, Jing ; Tian, Xiao ; von Deneen, Karen M. ; Zang, Yufeng ; Walter, Martin ; Liu, Yijun
刊名	神经科学快报
	2015
关键词	Obesity Regional homogeneity Resting state Functional magnetic resonance imaging Food intake REGIONAL HOMOGENEITY ACTIVATION TASK METAANALYSIS SATIATION CORTEX
DOI	10.1016/j.neulet.2014.10.020
英文摘要	Obesity as a chronic disease has become a global epidemic. However, why obese individuals eat more still remains unclear. Recent functional neuroimaging studies have found abnormal brain activations in obese people. In the present study, we used resting state functional MRI to observe spontaneous blood-oxygen-level dependent (BOLD) signal fluctuations during both hunger and satiety states in 20 lean and 20 obese men. Using a regional homogeneity (ReHo) analysis method, we measured temporal homogeneity of the regional BOLD signals. We found that, before food intake, obese men had significantly increased synchronicity of activity in the left putamen relative to lean men. Decreased synchronicity of activity was found in the orbitofrontal cortex (OFC) and medial prefrontal cortex(MPFC) in the obese subjects. And, the ratings of hunger of the obese subjects were higher than those of the lean subjects before food intake. After food intake, we did not find the significant differences between the obese men and the lean men. In all participations, synchronicity of activity increased from the fasted to the satiated state in the OFC. The results indicated that OFC plays an important role in feeding behavior, and OFC signaling may be disordered in obesity. Obese men show less inhibitory control during fasting state. This study has provided strong evidence supporting the hypothesis that there is a hypo-functioning reward circuitry in obese individuals, in which the frontal cortex may fail to inhibit the striatum, and consequently lead to overeating and obesity. (C) 2014 Elsevier Ireland Ltd. All rights reserved.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000347579000030&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Neurosciences; SCI(E); PubMed; 14; ARTICLE; tiandr@tijmu.edu.cn; 156-161; 584
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/188778]
专题	工学院
推荐引用方式 GB/T 7714	Zhang, Bin,Tian, Derun,Yu, Chunshui,et al. Altered baseline brain activities before food intake in obese men: A resting state fMRI study[J]. 神经科学快报,2015.
APA	Zhang, Bin.,Tian, Derun.,Yu, Chunshui.,Zhang, Jing.,Tian, Xiao.,...&Liu, Yijun.(2015).Altered baseline brain activities before food intake in obese men: A resting state fMRI study.神经科学快报.
MLA	Zhang, Bin,et al."Altered baseline brain activities before food intake in obese men: A resting state fMRI study".神经科学快报 (2015).