A metabolomic and pharmacokinetic study on the mechanism underlying the   lipid-lowering effect of orally administered berberine

doi:10.1039/c4mb00500g

CORC > 北京大学 > 工学院

	A metabolomic and pharmacokinetic study on the mechanism underlying the lipid-lowering effect of orally administered berberine
	Gu, Shenghua ; Cao, Bei ; Sun, Runbin ; Tang, Yueqing ; Paletta, Janice L. ; Wu, Xiao-Lei ; Liu, Linsheng ; Zha, Weibin ; Zhao, Chunyan ; Li, Yan ; Radlon, Jason M. ; Hylemon, Phillip B. ; Zhou, Huiping ; Aa, Jiye ; Wang, Guangji
刊名	分子生物系统
	2015
关键词	SALT HYDROLASE ACTIVITY GUT MICROBIOTA CLOSTRIDIUM-SCINDENS MASS-SPECTROMETRY CHOLIC-ACID MOUSE MODEL BILE LIVER MICE METABOLITES
DOI	10.1039/c4mb00500g
英文摘要	Clinical and animal studies demonstrated that orally administered berberine had a distinct lipid-lowering effect. However, pharmacokinetic studies showed that berberine was poorly absorbed into the body so the levels of berberine in the blood and target tissues were far below the effective concentrations revealed. To probe the underlying mechanism, the effect of berberine on the biological system was studied on a high-fat- diet-induced hamster hyperlipidemia model. Our results showed that intragastrically-administered berberine was poorly absorbed into circulation and most berberine accumulated in gut content. Although the bioavailability of intragastrically-administered berberine was much lower than that of intraperitoneally administered berberine, it had a stronger lipid-lowing effect, indicating that the gastrointestinal tract is a potential target for the hypolipidemic effect of berberine. A metabolomic study on both serum and gut content showed that orally administered berberine significantly regulated molecules involved in lipid metabolism, and increased the generation of bile acids in the hyperlipidemic model. DNA analysis revealed that the orally administered berberine modulated the gut microbiota, and berberine showed a significant inhibition of the 7 alpha-dehydroxylation conversion of cholic acid to deoxycholic acid, indicating a decreased elimination of bile acids in the gut. However, in model hamsters, elevated bile acids failed to downregulate the expression and function of CYP7A1 in a negative feedback loop. It was suggested that the hypocholesterolemic effect of orally administered berberine involves modulating the turnover of bile acids and the farnesoid X receptor signal pathway.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000348211900014&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Biochemistry & Molecular Biology; SCI(E); 2; ARTICLE; xiaolei_wu@pku.edu.cn; jiyea@cpu.edu.cn; 2; 463-474; 11
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/154118]
专题	工学院
推荐引用方式 GB/T 7714	Gu, Shenghua,Cao, Bei,Sun, Runbin,et al. A metabolomic and pharmacokinetic study on the mechanism underlying the lipid-lowering effect of orally administered berberine[J]. 分子生物系统,2015.
APA	Gu, Shenghua.,Cao, Bei.,Sun, Runbin.,Tang, Yueqing.,Paletta, Janice L..,...&Wang, Guangji.(2015).A metabolomic and pharmacokinetic study on the mechanism underlying the lipid-lowering effect of orally administered berberine.分子生物系统.
MLA	Gu, Shenghua,et al."A metabolomic and pharmacokinetic study on the mechanism underlying the lipid-lowering effect of orally administered berberine".分子生物系统 (2015).