Gold Nanoshelled Liquid Perfl uorocarbon Nanocapsules for Combined Dual   Modal Ultrasound/CT Imaging and Photothermal Therapy of Cancer

doi:10.1002/smll.201302252

CORC > 北京大学 > 工学院

	Gold Nanoshelled Liquid Perfl uorocarbon Nanocapsules for Combined Dual Modal Ultrasound/CT Imaging and Photothermal Therapy of Cancer
	Ke, Hengte ; Yue, Xiuli ; Wang, Jinrui ; Xing, Sen ; Zhang, Qian ; Dai, Zhifei ; Tian, Jie ; Wang, Shumin ; Jin, Yushen
刊名	small
	2014
关键词	gold nanoshell liquid perfluorocarbon ultrasound imaging CT imaging photothermal therapy RAY COMPUTED-TOMOGRAPHY CONTRAST AGENTS MACROPHAGE ENDOCYTOSIS OPTICAL-PROPERTIES NANOPARTICLES HYPERTHERMIA RADIATION NANOCAGES NANORODS TUMORS
DOI	10.1002/smll.201302252
英文摘要	The integration of multimodal contrast-enhanced diagnostic imaging and therapeutic capabilities could utilize imaging guided therapy to plan the treatment strategy based on the diagnostic results and to guide/monitor the therapeutic procedures. Herein, gold nanoshelled perfluorooctylbromide (PFOB) nanocapsules with PEGylation (PGsP NCs) are constructed by oil-in-water emulsion method to form polymeric PFOB nanocapsules, followed by the formation of PEGylated gold nanoshell on the surface. PGsP NCs could not only provide excellent contrast enhancement for dual modal ultrasound and CT imaging in vitro and in vivo, but also serve as efficient photoabsorbers for photothermal ablation of tumors on xenografted nude mouse model. To our best knowledge, this is the first report of gold nanoshell serving as both CT contrast agents and photoabsorbers for photothermal therapy. The novel multifunctional nanomedicine would be of great value to offer more comprehensive diagnostic information to guide more accurate and effective cancer therapy.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000333538000024&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter; SCI(E); EI; PubMed; 18; ARTICLE; zhifei.dai@pku.edu.cn; jie.tian@ia.ac.cn; 6; 1220-1227; 10
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/153898]
专题	工学院
推荐引用方式 GB/T 7714	Ke, Hengte,Yue, Xiuli,Wang, Jinrui,et al. Gold Nanoshelled Liquid Perfl uorocarbon Nanocapsules for Combined Dual Modal Ultrasound/CT Imaging and Photothermal Therapy of Cancer[J]. small,2014.
APA	Ke, Hengte.,Yue, Xiuli.,Wang, Jinrui.,Xing, Sen.,Zhang, Qian.,...&Jin, Yushen.(2014).Gold Nanoshelled Liquid Perfl uorocarbon Nanocapsules for Combined Dual Modal Ultrasound/CT Imaging and Photothermal Therapy of Cancer.small.
MLA	Ke, Hengte,et al."Gold Nanoshelled Liquid Perfl uorocarbon Nanocapsules for Combined Dual Modal Ultrasound/CT Imaging and Photothermal Therapy of Cancer".small (2014).