Implantable and self-powered blood pressure monitoring based on a   piezoelectric thinfilm: Simulated, in vitro and in vivo studies

doi:10.1016/j.nanoen.2016.02.037

CORC > 北京大学 > 信息科学技术学院

	Implantable and self-powered blood pressure monitoring based on a piezoelectric thinfilm: Simulated, in vitro and in vivo studies
	Cheng, Xiaoliang ; Xue, Xiang ; Ma, Ye ; Han, Mengdi ; Zhang, Wei ; Xu, Zhiyun ; Zhang, Hao ; Zhang, Haixia
刊名	NANO ENERGY
	2016
关键词	Self-powered Piezoelectric material Biomedical monitor Blood pressure Implantable device HARVESTING ENERGY HYBRID NANOGENERATOR BIOMECHANICAL ENERGY MECHANICAL ENERGY GENERATOR SYSTEM PACEMAKER HEART
DOI	10.1016/j.nanoen.2016.02.037
英文摘要	This research is aimed to evaluate the feasibility and efficacy of a piezoelectric thinfilm (PETF) based, implantable and self-powered monitor for blood pressure (BP) through theoretical, in vitro and in vivo studies. A 3-dimensional simulation model revealed that both the stresses of aorta wall and the generated electric potential by device were proportional to systolic BP. With an in vitro testing system, an excellent linearity (R-2 > 0.99) was achieved between the peak output voltage of device and flow pressure, with a high-sensitivity of 173 mV/mmHg which is significantly higher than reported results. A maximum instantaneous power of 2.3 mu W was reached in vitro, indicating a robust self-powered capability. Excellent stability of the device was also achieved for more than 50,000 operating cycles. In vivo experiment was carried out in adult Yorkshire porcine. A favorable linearity (R-2=0.971) with a sensitivity of 1432 mV/mmHg was obtained, and the device output a maximal instantaneous power of 40 nW in vivo. Based on these characteristics of the device, we established an implantable, self-powered and visualized blood pressure monitoring system for in vitro and in vivo demonstration. A hypertension status could be alarmed visually in real-time using this system, without a built-in battery. Integrated with a coupling function of energy harvesting and biomedical sensing, this new technique shows a promising perspective in the field of the implantable healthcare monitoring. (C) 2016 Elsevier Ltd. All rights reserved.; National Natural Science Foundation of China [61176103, 91323304, 81271707, 81371692, 30700157]; National Hi-Tech Research and Development Program of China ("863" Project) [2013AA041102]; Natural Science Foundation of Beijing Municipality, China [4141002]; SCI(E); EI; ARTICLE; zhanghao@smmu.edu.cn; zhang-alice@pku.edu.cn; 453-460; 22
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/437508]
专题	信息科学技术学院
推荐引用方式 GB/T 7714	Cheng, Xiaoliang,Xue, Xiang,Ma, Ye,et al. Implantable and self-powered blood pressure monitoring based on a piezoelectric thinfilm: Simulated, in vitro and in vivo studies[J]. NANO ENERGY,2016.
APA	Cheng, Xiaoliang.,Xue, Xiang.,Ma, Ye.,Han, Mengdi.,Zhang, Wei.,...&Zhang, Haixia.(2016).Implantable and self-powered blood pressure monitoring based on a piezoelectric thinfilm: Simulated, in vitro and in vivo studies.NANO ENERGY.
MLA	Cheng, Xiaoliang,et al."Implantable and self-powered blood pressure monitoring based on a piezoelectric thinfilm: Simulated, in vitro and in vivo studies".NANO ENERGY (2016).