Design, simulation and experimental validation of a novel flexible   neural probe for deep brain stimulation and multichannel recording

doi:10.1088/1741-2560/9/3/036001

CORC > 北京大学 > 信息科学技术学院

	Design, simulation and experimental validation of a novel flexible neural probe for deep brain stimulation and multichannel recording
	Lai, Hsin-Yi ; Liao, Lun-De ; Lin, Chin-Teng ; Hsu, Jui-Hsiang ; He, Xin ; Chen, You-Yin ; Chang, Jyh-Yeong ; Chen, Hui-Fen ; Tsang, Siny ; Shih, Yen-Yu I.
刊名	journal of neural engineering
	2012
关键词	SILICON MICROELECTRODE ARRAYS ELECTRICAL-STIMULATION PARKINSONS-DISEASE FIBER STIMULATION UNIT RECORDINGS SCIATIC-NERVE TISSUE ELECTRODE ACTIVATION IMPEDANCE
DOI	10.1088/1741-2560/9/3/036001
英文摘要	An implantable micromachined neural probe with multichannel electrode arrays for both neural signal recording and electrical stimulation was designed, simulated and experimentally validated for deep brain stimulation (DBS) applications. The developed probe has a rough three-dimensional microstructure on the electrode surface to maximize the electrode-tissue contact area. The flexible, polyimide-based microelectrode arrays were each composed of a long shaft (14.9 mm in length) and 16 electrodes (5 mu m thick and with a diameter of 16 mu m). The ability of these arrays to record and stimulate specific areas in a rat brain was evaluated. Moreover, we have developed a finite element model (FEM) applied to an electric field to evaluate the volume of tissue activated (VTA) by DBS as a function of the stimulation parameters. The signal-to-noise ratio ranged from 4.4 to 5 over a 50 day recording period, indicating that the laboratory-designed neural probe is reliable and may be used successfully for long-term recordings. The somatosensory evoked potential (SSEP) obtained by thalamic stimulations and in vivo electrode-electrolyte interface impedance measurements was stable for 50 days and demonstrated that the neural probe is feasible for long-term stimulation. A strongly linear (positive correlation) relationship was observed among the simulated VTA, the absolute value of the SSEP during the 200 ms post-stimulus period (Sigma SSEP) and c-Fos expression, indicating that the simulated VTA has perfect sensitivity to predict the evoked responses (c-Fos expression). This laboratory-designed neural probe and its FEM simulation represent a simple, functionally effective technique for studying DBS and neural recordings in animal models.; Engineering, Biomedical; Neurosciences; SCI(E); EI; 0; ARTICLE; 3; 9
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/393285]
专题	信息科学技术学院
推荐引用方式 GB/T 7714	Lai, Hsin-Yi,Liao, Lun-De,Lin, Chin-Teng,et al. Design, simulation and experimental validation of a novel flexible neural probe for deep brain stimulation and multichannel recording[J]. journal of neural engineering,2012.
APA	Lai, Hsin-Yi.,Liao, Lun-De.,Lin, Chin-Teng.,Hsu, Jui-Hsiang.,He, Xin.,...&Shih, Yen-Yu I..(2012).Design, simulation and experimental validation of a novel flexible neural probe for deep brain stimulation and multichannel recording.journal of neural engineering.
MLA	Lai, Hsin-Yi,et al."Design, simulation and experimental validation of a novel flexible neural probe for deep brain stimulation and multichannel recording".journal of neural engineering (2012).